迪fference between dosimeter and tidal breathing methacholine challenge: contributions of dose and deep inspiration bronchoprotection
- PMID:16354875
- doi:10.1378/胸部128.6.4018
迪fference between dosimeter and tidal breathing methacholine challenge: contributions of dose and deep inspiration bronchoprotection
抽象的
背景:两种支气管前置方法被广泛使用。与潮汐呼吸方法相比,剂量计方法可提供大约一半的剂量,并涉及五个深入吸入。下剂量和支气管保护深入吸入都会有助于剂量计的较小气道反应。
Objective:To determine the relative role of dose and deep inspiration in the difference between the two methods.
方法:Subjects with asthma (n = 24) underwent three methacholine challenges: a dosimeter challenge, a 2-min tidal breathing challenge (twice the dose), and a modified 2-min tidal breathing challenge (twice the dose plus five deep inhalations).
Results:The dosimeter method produced a nonsignificantly lower response than the modified tidal breathing method (p = 0.14). Both deep inhalation methods produced significantly less response than did the standard tidal breathing method (p = 0.011). In the 12 subjects with the most mild airway hyperresponsiveness (AHR), the differences between the deep inhalation method and the tidal breathing method were greater (p = 0.007). By contrast, deep inhalations produced no effect in the 12 subjects with greater AHR; the two tidal breathing methods produced identical results, while the dosimeter produced less response than either (p = 0.033). Six current asthmatics with mild airway responsiveness (tidal breathing method) had negative dosimeter methacholine challenge results.
结论:在具有中等气道反应性的受试者中,方法之间的差异是由于剂量差异引起的,而在轻度AHR的受试者中,深层吸入的剂量效果很大,剂量效应并产生假阴性甲基苯胺挑战,导致25%的剂量效果。主题。
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