确定需要一份固定格式的自我完成问卷来测量慢性气流受限的健康状况。制定了一份76项的问卷，即圣乔治呼吸问卷(SGRQ)。计算了三个组成部分的分数:症状、活动和(对日常生活的)影响，以及总分。进行了三项研究。(1)对40例稳定型哮喘患者和20例稳定型COPD患者进行2周以上重复性试验。SGRQ总分的变异系数为19%。(2)将SGRQ评分与肺功能测定法、6分钟步行距离(6-MWD)、MRC呼吸症状问卷、焦虑、抑郁和使用疾病影响评分测量的一般健康进行比较。141例患者接受了研究，平均年龄63岁(范围31 - 75岁)和支气管扩张剂前FEV1, 47%(范围11 - 114%)。SGRQ得分与适当的比较措施相关。如症状评分与喘息频率的关系，r2 = 0.32, p < 0.0001; activity versus 6-MWD, r2 = 0.50, p less than 0.0001; impact versus anxiety, r2 = 0.38, p less than 0.0001. Multivariate analysis demonstrated that SGRQ scores summed a number of areas of disease activity. (3) Changes in SGRQ scores and other measures were studied over 1 yr in 133 patients. Significant correlations were found between changes in SGRQ scores and the comparison measures (minimum r2 greater than 0.05, p less than 0.01). Multivariate analysis showed that change in total SGRQ score summed changes in a number of aspects of disease activity. We conclude that the SGRQ is a valid measure of impaired health in diseases of chronic airflow limitation that is repeatable and sensitive.