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Home/The International Journal of Tuberculosis and Lung Disease, Volume 16, Number 4

Free ContentClinical use of the meropenem-clavulanate combination for extensively drug-resistant tuberculosis [Case study]

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Mycobacterium tuberculosisstrains resistant to almost all available anti-tuberculosis drugs are an increasing threat to public health worldwide. Among existing drugs with potential antimycobacterial effects, the combination of meropenem with clavulanate has been shown to have potent in vitro bactericidal activity against extensively drug-resistant tuberculosis (XDR-TB). To explore its potential clinical efficacy, a meropenem-clavulanate-containing salvage regimen was started in six patients with severe pulmonary XDR-TB, in association with the only one or two remaining active second-line drugs. Encouraging preliminary data are detailed and discussed.

Keywords:carbapenems plus clavulanate;extensively drug-resistant tuberculosis;salvage therapy

Document Type:Research Article

Affiliations:1:Department of Infectious Diseases, Centre Hospitalier Universitaire Saint-Pierre, Brussels, Belgium2:Department of Pneumology, Centre Hospitalier Universitaire Saint-Pierre, Brussels, Belgium

Publication date: 01 April 2012

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