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坚持CPAP疗法改善生活质量and reduces symptoms among obstructive sleep apnea syndrome patients

Sleep and Breathingvolume16,pages563–569 (2012)Cite this article

Abstract

目的

The aim of the study was to asses quality of life and symptoms of obstructive sleep apnea syndrome (OSAS) patients after adhering to 6 months of continuous positive airway pressure (CPAP) treatment.

Methods

一组50例患者（41名男性和9名女性）通过多摄影术诊断，并接受CPAP治疗6个月。他们的症状和与健康相关的生活质量通过管理睡眠呼吸暂停生活质量指数（SAQLI）的经过验证和翻译的版本来评估。使用Epworth嗜睡量表（ESS）和通过电子监测CPAP使用每晚睡眠来测量嗜睡。

Results

Mean CPAP usage was 4.5 ± 0.5 h per night. Comparisons between quality of life indexes before and after CPAP treatment showed an improvement in the total SAQLI score (3.8 ± 0.9 vs. 5.8 ± 0.8 after CPAP,p < 0.01), in daily functioning (4.2 ± 1.4 vs. 6.0 ± 0.9,p < 0.01), social interactions (4.8 ± 1.3 vs.6.3 ± 0.7,p < 0.01), emotional functioning (4.4 ± 1.4 vs. 5.7 ± 1.0,p < 0.01), symptoms (1.6 ± 0.8 vs. 5.8 ± 1.2,p < 0.01), and in the ESS (13.7 ± 6.5 vs. 3.9 ± 3.8,p < 0.01). Regarding the patients’ symptoms, improvement was noticed for “sleepiness while watching a spectacle” (96%), “reading” (95%), “carrying on a conversation” (95%), “driving” (92.9%), “restless sleep” (87.8%), and “urinating more than once per night” (84.8%). Smaller improvements were observed for the reported “dry mouth–throat upon awakening” (36.1%),“excessive fatigue” (54.5%), and “decreased energy” (55.3%).

Conclusion

We conclude that OSAS patients who adhere to nighttime CPAP therapy show significant improvement of their quality of life, daytime sleepiness, and other symptoms after 6 months of treatment with CPAP.

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参考

  1. Qureshi A, Ballard RD (2003) Current reviews of allergy and clinical immunology of obstructive sleep apnea syndrome. J Allergy Clin Immunol 112(4):643–651

    PubMedArticle谷歌学术

  2. Akashiba T, Kawahara S, Akahoshi T, Omori C, Osamu S, MajimaT HT (2002) Relationship between quality of life and mood or depression in patients with severe obstructive sleep apnea syndrome. Chest 122:861–865

    PubMedArticle谷歌学术

  3. Melamed S, Oksenberg A (2002) Excessive daytime sleepiness and risk of occupational injuries in non shift daytime workers. Sleep 25:315–322

    PubMed谷歌学术

  4. Lioberes P，Levy C，Descals D，Sampol G，Roca A，Sagales T，La Calzada D（2000）自我报道了嗜睡，同时驱动了OSA和非副词的患者的交通事故。Respir Med 94：971–976

    Article谷歌学术

  5. Lioberes P, Marti S, Sampol G, Roca A, Sagales T, Munoz X, Ferrer M (2004) Predictive factors of quality of life improvement and continuous positive airway pressure use in patients with sleep apnea hypopnea syndrome: study at 1 year. Chest 126:1241–1247

    Article谷歌学术

  6. Zozula R，Rosen R（2001）遵守持续阳性气道压力疗法：评估和改善治疗结果。Curr Opin Pulm Med 7：391–398

    PubMedArticleCAS谷歌学术

  7. Reeves-Hoche MK, Meck R, Zwillich CW (1994) Nasal CPAP: an objective evaluation of patient compliance. Am J Respir Crit Care Med 149(1):149–154

    PubMedCAS谷歌学术

  8. Sanner BM, Klewer J, Trumm A, Randerath W, Kreuzer I, Zidek W (2000) Long-term treatment with continuous positive airway pressure improves quality of life in obstructive sleep apnea syndrome. Eur Respir J 16:118–122

    PubMedArticleCAS谷歌学术

  9. Pichel F, Zamarron C, Magan F, del Campo F, Alvarez-Sala R, Suarez JR (2004) Health related quality of life in patients with obstructive sleep apnea: effects of long-term positive airway pressure treatment. Respir Med 98:968–976

    PubMedArticleCAS谷歌学术

  10. Flemons WW, Reimer MA (2000) The Calgary sleep apnea quality of life index (manual). The University of Calgary, Alberta, Canada

    谷歌学术

  11. Flemons WW, Reimer MA (1998) Development of a disease specific health related quality of life questionnaire for sleep apnea. Am J Respir Crit Care Med 158:494–503

    PubMedCAS谷歌学术

  12. Skomto R, Kryger M (1999) Clinical presentations of OSAS. Prog Cardiovasc Dis 5:331–340

    Article谷歌学术

  13. Kribbs NB, Pack AI, Kline LR, Smith PL, Schwartz AR, Schubert NM, Redline S, Henry JN, Getsy JE, Dinges DF (1993) Objective measurement of patterns of nasal CPAP use by patients with obstructive sleep apnea. Am Rev Respir Dis 147:887–895

    PubMedCAS谷歌学术

  14. Monasterio C, Vidal S, Duran J, Ferrer M, Carmona C, Barbé F, Mayos M, Gonzalez-Mangado N, Juncadella M, Navarro A, Barreira R, Capote F, Mayoralas LR, Peces-Barba G, Alonso J, Montserrat JM (2001) Effectiveness of continuous positive airway pressure in mild sleep apnea–hypopnea syndrome. Am J Respir Crit Care Med 164:939–943

    PubMedCAS谷歌学术

  15. Redline S，Strauss ME，Adams N，Winters M，Roebuck T，Spry K，Rosenberg C，Adams K（1997）轻度睡眠失调的呼吸中的神经心理学功能。睡眠20：160–167

    PubMedCAS谷歌学术

  16. Gall R, Isaac L, Kriger M (1993) Quality of life in mild obstructive sleep apnea. Sleep 16:S59–S61

    PubMedCAS谷歌学术

  17. Teran-Santos J, Jimenez-Gomez A, Cordero-Guevara J (1999) The association between sleep apnea and the risk of traffic accidents. N Engl J Med 340:847–851

    PubMedArticleCAS谷歌学术

  18. Young T，Pepperd P，Palta M，Mae K，Finn L，Morgan B，Skartrud J（1997）基于人群的睡眠呼吸研究是高血压的危险因素。Arch Intern Med 157：1746–1752

    PubMedArticleCAS谷歌学术

  19. Ronald D, Chervin MD (2000) Sleepiness, fatigue, tiredeness and lack of energy in obstructive sleep apnea. Chest 118:372–379

    Article谷歌学术

  20. Engelman HM, Martin SE, Deary IJ, Douglas NJ (1997) Effect of CPAP therapy on daytime function in patients with mild sleep apnea/hypopnea syndrome. Thorax 52:114–119

    Article谷歌学术

  21. Collard P, Pieters T, Aubert G, Delguste P, Rodenstein D (1997) Compliance with nasal CPAP in obstructive sleep apnea patients. Sleep Med Rev 1:33–44

    PubMedArticleCAS谷歌学术

  22. Engelman HM, Martin SE, Douglas NJ (1994) Compliance with CPAP therapy in patients with the sleep apnea/hypopnea syndrome. Thorax 49:263–266

    Article谷歌学术

  23. Hui DS, Choy DK, Lu TS, Ko FW, Wong KK, Chan JK, Lai CK (2001) Determinants of continuous positive airway ressure in agroup of Chinese patients with obstructive sleep apnea. Chest 120:170–176

    PubMedArticleCAS谷歌学术

  24. Sin DD，Mayers I，Man GCW，Ghahary A和Pawluk L（2003）可以连续阳性气道压力疗法改善阻塞性睡眠呼吸暂停患者的一般健康状况吗？：一项临床有效性研究。胸部112（5）：1679–1685

    谷歌学术

  25. Engelman HM, Kingshott RN, Wraith PK, Mackay TW, Deary IJ, Douglas NJ (1999) Randomized placebo-controlled crossover trial of continuous positive airway pressure for mild sleep apnea/hypopnea syndrome. Am J Respir Crit Care Med 159:461–467

    谷歌学术

  26. Barnes M, Houston D, Worsnop CJ, Neill AM, Mykytyn IJ, Kay A, Trinder J, Saunders NA, Mc Evoy D, Pierce R (2002) A randomized controlled trial of continuous positive airway pressure in mild obstructive sleep apnea. Am J Respir Crit Care Med 165:773–780

    PubMed谷歌学术

  27. Boudewyns A, Willemen M, Wagemans M, De Cock W, De Backer W, Van de Heyhing P (1996) Improvement of the Epworth Sleepiness Score after long term CPAP or BiPAP treatment in sleep apnea patients. Sleep 25:214–220

    谷歌学术

  28. Ryan S, Doherty LS, Nolan GM, Mc Nicholas WT (2009) Effects of heated humidification and topical steroids on compliance, nasal symptoms, and quality of life in patients with obstructive sleep apnea syndrome using nasal continuous positive airway pressure. J Clin Sleep Med 5:422–427

    PubMed谷歌学术

  29. Wiegand DM, Hanowski RJ, McDonald SE (2009) Commercial drivers’ health: a naturalistic study of body mass index, fatigue and involvement in safety-critical events. Traffic Inj Prev 10:573–579

    PubMedArticle谷歌学术

  30. Redenius R, Murphy C, O’Neill E, Al-Hamwi M, Zallek SN (2008) Does CPAP lead to change in BMI? J Clin Sleep Med 210–211

  31. Wysocka E, Cofta S, Cymetys M, Gozdzik J, Torlinski L, Batura-Gabryel H (2008) The impact of the sleep apnea syndrome on oxidant-antioxidant balance in the blood of overweight and obese patients. J Physiol Pharmacol 59:761–769

    PubMed谷歌学术

  32. Randerath W,鲍尔M,蓝色,Fietze我Galetke W,Hein H, Maurer JT, Orth M, Rasche K, Ruhle KH, Sanner F, Stuck BA, Verse T (2007) Are there alternative therapeutical options other than CPAP in the treatment of the obstructive sleep apnea syndrome? Pneumologie 61:458–466

    PubMedArticleCAS谷歌学术

  33. Strobel RJ，Rosen RC（1996）阻塞性睡眠呼吸暂停中的肥胖和体重减轻：一项关键评论。睡眠19：104–115

    PubMedCAS谷歌学术

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Acknowledgments

This project was partially supported by the HEART project (Hellenic Action for Research against Tobacco) by the Behrakis Foundation to the Smoking and Lung Cancer Research Center of the Hellenic Cancer Society. The authors would like to thank Prof. Gregory Connolly for his support and participation through the HEART Study.

Conflict of interest

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Affiliations

  1. Sleep Laboratory, Henry Dunant Hospital, Athens, Greece

    Eirini Avlonitou, Fotis Kapsimalis & George Varouchakis

  2. Smoking and Lung Cancer Research Center, Hellenic Cancer Society, 8 Dorilaiou Street Ampelokipoi, 11521, Athens, Greece

    Constantine I. Vardavas & Panagiotis Behrakis

  3. Laboratory of Physiology, School of Medicine, University of Athens, Athens, Greece

    Panagiotis Behrakis

Authors
  1. Eirini Avlonitou
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  2. Fotis Kapsimalis
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  3. George Varouchakis
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  4. Constantine I. Vardavas
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  5. Panagiotis Behrakis
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Corresponding author

Correspondence toConstantine I. Vardavas.

Additional information

Conference presentations

部分this work has been presented in the 19th Congress of the European Sleep Research Society (ESRS), Glasgow, 9–13 September2008 and also in the CHEST Conference, Chicago, Illinois, 20–25 October 2007.

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Avlonitou, E., Kapsimalis, F., Varouchakis, G.et al.坚持CPAP疗法改善生活质量and reduces symptoms among obstructive sleep apnea syndrome patients.Sleep Breath16,563–569 (2012). https://doi.org/10.1007/s11325-011-0543-8

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  • DOI:https://doi.org/10.1007/s11325-011-0543-8

Keywords

  • OSAS
  • CPAP
  • Quality of life
  • Adherence
  • Apnea