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Glucocorticoid-induced hypertension

Pediatric Nephrology体积27,页面1059–1066 (2012年)Cite this article

Abstract

Glucocorticoid-induced hypertension is a common clinical problem that is poorly understood, thus rendering treatment strategies sub-optimal. This form of hypertension has been commonly thought to be mediated by excess sodium and water reabsorption by the renal mineralocorticoid receptor. However, experimental and clinical data in both humans and animal models suggest important roles for the glucocorticoid receptor as well, in both the pathogenesis and maintenance of this hypertension. The glucocorticoid receptor is widely expressed in a number of organ systems relevant to blood pressure regulation, including the kidney, the brain and the vasculature. In vitro studies in isolated kidney tissues as well as in vascular smooth muscle and vascular endothelial cells have attempted to elucidate the molecular physiology of glucocorticoid-induced hypertension, but have generally been limited by the inability to study signaling pathways in an intact organism. More recently, the power of mouse genetics has been employed to examine the tissue-specific contributions of vascular and extra-vascular tissues to this form of hypertension. Here we review recent developments in our understanding of the pathogenesis of glucocorticoid-induced hypertension.

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作者信息

隶属关系

  1. 耶鲁大学医学院儿科，333雪松街，邮政编码，纽黑文，CT，06520

    Julie E. Goodwin

  2. 耶鲁大学医学院肾脏肾病，纽黑文，CT，06520-8029

    David S. Geller.

  3. 医学系，退伍军人事务医疗中心，西哈文，CT，06516，USA

    David S. Geller.

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  1. Julie E. Goodwin
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Goodwin，J.E.，Geller，D.S.糖皮质激素诱导的高血压。Pediastre inphrol.27，1059–1066 (2012). https://doi.org/10.1007/s00467-011-1928-4

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  • DOI:https://doi.org/10.1007/s00467-011-1928-4

关键词

  • 高血压
  • Glucocorticoid receptor
  • Mouse model
  • Vascular smooth muscle
  • Endothelium
  • Nitric oxide