Spring | Summer | Autumn | Winter | |||||
PEF | Exacerbation | PEF | Exacerbation | PEF | Exacerbation | PEF | Exacerbation | |
PM2.5 | −0.011 (−0.059–0.037) |
0.986 (0.975–0.997)* |
−0.122 (0.186 - 0.058−−)* |
1.010 (1.000–1.021)* |
0.012 (−0.041–0.065) |
1.000 (0.994–1.005) |
0.018 (−0.018–0.053) |
0.995 (0.990–0.999)* |
PM10 | −0.003 (−0.042–0.035) |
1.001 (0.993–1.010) |
−0.063 (−0.113– −0.014)* |
1.006 (0.998–1.015) |
0.006 (−0.048–0.060) |
1.000 (0.994–1.005) |
0.011 (−0.027–0.049) |
0.992 (0.987–0.998)* |
NO2 | −0.119 (−0.248–0.011) |
1.008 (0.982–1.034) |
0.059 (−0.156–0.275) |
1.024 (0.976–1.074) |
−0.115 (−0.368–0.138) |
1.003 (0.964–1.043) |
0.063 (−0.092–0.218) |
0.970 (0.942–0.999)* |
NO | 0.034 (−0.136–0.205) |
1.000 (0.970–1.031) |
−0.027 (−0.171 - -0.117) |
1.030 (0.988–1.073) |
0.002 (−0.084–0.088) |
1.002 (0.990–1.014) |
−0.006 (−0.058–0.046) |
1.009 (1.001–1.017)* |
CO¶ | −0.009 (−0.082–0.064) |
0.996 (0.982–1.011) |
0.052 (−0.031–0.135) |
1.001 (0.985–1.018) |
−0.096 (−0.209–0.016) |
1.005 (0.988–1.022) |
−0.012 (−0.074–0.050) |
1.007 (0.995–1.018) |
O3 | 0.009 (−0.113–0.132) |
1.028 (1.004–1.052)* |
0.035 (−0.099–0.169) |
1.016 (0.987–1.045) |
−0.169 (−0.515–0.177) |
0.969 (0.913–1.029) |
0.008 (−0.411–0.427) |
1.149 (1.074–1.229)* |
Data are presented as estimated change in PEF (L·min−1)或f比值比or exacerbation with 95% confidence interval by season per unit increase (models adjusted for age, sex, chronic obstructive pulmonary disease severity, Index of Multiple Deprivation rank, inhaled corticosteroid medication use, temperature and time). PM2.5: particulate matter with aerodynamic diameter <2.5 μm; PM10: particulate matter with aerodynamic diameter <10 μm; NO2: nitrogen dioxide; NO: nitric oxide; CO: carbon monoxide; O3: ozone.#: spring n=4495, summer n=4507, autumn n=2769, winter n=2969;¶: per 0.01 ppm increase. *: statistically significant estimates (p<0.05).