TY -的T1 wi相关气道壁厚th forced expiratory volume in 1 second decline and development of airflow limitation JF - European Respiratory Journal JO - Eur Respir J SP - 644 LP - 651 DO - 10.1183/09031936.00020714 VL - 45 IS - 3 AU - Mohamed Hoesein, Firdaus A.A. AU - de Jong, Pim A. AU - Lammers, Jan-Willem J. AU - Mali, Willem P.T.M. AU - Schmidt, Michael AU - de Koning, Harry J. AU - van der Aalst, Carlijn AU - Oudkerk, Matthijs AU - Vliegenthart, Rozemarijn AU - Groen, Harry J.M. AU - van Ginneken, Bram AU - van Rikxoort, Eva M. AU - Zanen, Pieter Y1 - 2015/03/01 UR - //www.qdcxjkg.com/content/45/3/644.abstract N2 - Airway wall thickness and emphysema contribute to airflow limitation. We examined their association with lung function decline and development of airflow limitation in 2021 male smokers with and without airflow limitation. Airway wall thickness and emphysema were quantified on chest computed tomography and expressed as the square root of wall area of a 10-mm lumen perimeter (Pi10) and the 15th percentile method (Perc15), respectively. Baseline and follow-up (median (interquartile range) 3 (2.9–3.1) years) spirometry was available. Pi10 and Perc15 correlated with baseline forced expiratory volume in 1 s (FEV1) (r= −0.49 and 0.11, respectively (p<0.001)). Multiple linear regression showed that Pi10 and Perc15 at baseline were associated with a lower FEV1 after follow-up (p<0.05). For each sd increase in Pi10 and decrease in Perc15 the FEV1 decreased by 20 mL and 30.2 mL, respectively. The odds ratio for developing airflow limitation after 3 years was 2.45 for a 1-mm higher Pi10 and 1.46 for a 10-HU lower Perc15 (p<0.001). A greater degree of airway wall thickness and emphysema was associated with a higher FEV1 decline and development of airflow limitation after 3 years of follow-up. Computed tomography airway wall thickness and emphysema are associated with lung function decline and COPD http://ow.ly/DMN4h ER -