TY - JOUR T1 - Long-term outcomes and prognostic factors for neuroendocrine G1 and G2 lung tumors JF - European Respiratory Journal JO - Eur Respir J VL - 40 IS - Suppl 56 SP - P4177 AU - Wälscher, Julia AU - Weinreich, Gerhard AU - Theegarten, Dirk AU - Ting, Saskia AU - Tannapfel, Andrea AU - Stamatis, Georgios Y1 - 2012/09/01 UR - //www.qdcxjkg.com/content/40/Suppl_56/P4177.abstract N2 - Background: Bronchial neuroendocrine G1 and G2 tumors show a favorable outcome.However,survival depends on several prognostic factors such as histological sub-type,nodal involvement and other predictors.Objectives:The presented study aimed to evaluate the long-term outcomes,survival rates and prognostic factors after resection of G1 and G2 neuroendocrine lung tumors according to the 7th edition of the TNM staging system.Patients and methods: We conducted a retrospective review of 246 consecutive patients who underwent surgical treatment for G1 and G2 neuroendocrine tumors of the lung between 1998-2010.Results: 246 patients(61% women)with G1 and G2 neuroendocrine lung tumor underwent thoracotomy.G1 tumors were found in 205(83%)patients,while 41(17%)had G2 disease.Follow-up was 65.9±40.3 months.In the total study cohort we analysed 5- and 10-year survival:G1 bronchopulmonary tumor(survival 96% and 94%)was significantly different(p<0.001)from G2 bronchopulmonary tumor(survival 87% and 46%),stage I(survival 94% and 85%)was significantly different(p=0.02)from stage >I(survival 86% and 59%),nodal involvement(survival 83% and 57%)was significantly different(p=0.02)in comparison to patients without nodal involvement(survival 94% and 84%),distant metastases(survival 80% and 27%)was significantly different(p=0.001)compared to patients without distant metastases (survival 94% and 84%),occurrence of symptoms before operation(survival 96% and 84%)was significantly different from patients presenting no symptoms before operation(survival 86% and 67%).Conclusion: Prognosis was influenced by histological subtype,stage of disease,occurrence of symptoms before operation,lymph node involvement and distant metastases.ER-