ty -jour t1-使用纳米材料基于基于纳米材料的传感器JF检测活性肺结核测试 - 欧洲呼吸杂志K. au -Jeries，Raneen au -Gharra，A'laa au -Binder，Anke Au -Broza，Yoav Y. Au -Pascoe，Mellissa au -dheda -keertan au -keertan au -haick -haick，Hossam Y1- 2014/05/01 ur--05/01 Ur--//www.qdcxjkg.com/content/43/5/1522.abstract N2-向编辑者：检测活跃的结核病（TB）仍然是全球的主要公共卫生挑战[1]。结核蛋白皮肤测试不会区分潜在的活性结核[2]。干扰素释放测定法具有相似的局限性[3]。痰的酸性杆菌染色具有高的假阴性率（高达50％）[4]。核酸扩增测试（NAATS），例如GenExpert MTB/RIF（Cepheid，Cepheid，Sunnyvale，CA，USA）是准确的，但需要良好的基础设施，并且有必要获得质量质量的痰样品，通常在比A多于A中无法获得的痰液样本三分之一的HIV感染者[5，6]。启动了这些未满足的需求，我们探索了一种新颖，快速，简单和廉价的护理测试来诊断结核病[7]。该方法基于检测从感染细胞发出并在呼出的呼吸中释放的挥发性有机化合物（VOC）[8，9]。使用与质谱法相关的气相色谱法，研究人员先前已经报道了呼出的呼吸中与TB相关的VOC的鉴定，尽管检测准确性较低（80-85％）[10]。 In this study, we explore the possibility of active TB detection via the analysis of exhaled breath using a novel technology of organically modified nanomaterial-based sensors. Such cross-reactive sensors are highly sensitive to the collective changes in the VOCs spectrum [8].Therefore, we designed a case–control study, in which breath and sputum sampling was performed in 210 adult participants, after informed consent, at three sites in Cape Town, South Africa, between November 2011 and March 2012. The study population consisted of two main subgroups. The first subgroup included those in … ER -