@article {Kistemaker1677作者={卫矛E.M. Kistemaker I.S.T. Bos和经济分析家n . Hylkema卡坦c . Nawijn先生和Pieter s Hiemstra和J {\ " u} rgen韦斯赫尔曼•穆尔和Huib点Kerstjens Reinoud Gosens}, title ={毒蕈碱的受体subtype-specific影响香烟烟雾诱发小鼠炎症},体积={42}={6},页面= {1677 - 1688}= {2013},doi ={10.1183/09031936.00112412},出版商={欧洲呼吸学会},文摘={胆碱能语气导致气流阻塞在慢性阻塞性肺疾病。188bet官网地址因此,抗胆碱能类是有效的支气管扩张剂通过阻断气道平滑肌的毒蕈碱的M3受体。最近的证据表明,乙酰胆碱也会导致气道炎症。然而,毒蕈碱的受体亚型(s)调节这一过程是未知的。在这项研究中,贡献的M1, M2和M3受体亚型在香烟烟雾诱发气道炎症被公开调查毒蕈碱的受体亚型缺乏老鼠吸烟4天。在野生型小鼠,香烟的烟雾诱导巨噬细胞的增加,中性粒细胞和淋巴细胞在支气管肺泡灌洗液。中性粒细胞炎症是高M1 - / -和M2 - / -小鼠与野生型小鼠相比,但在M3 - / -小鼠低。因此,keratinocyte-derived趋化因子的释放(KC)、单核细胞趋化蛋白1和白细胞介素- 6在M1 - / -和M2 - / -小鼠,并减少在M3 - / -小鼠。标记的改造香烟烟雾暴露后并没有增加。然而,M3 - / -小鼠蛋白质转换增长factor-β1和矩阵的表达式。 Cigarette smoke-induced inflammatory cell recruitment and KC release were also prevented by the M3-receptor selective antagonist 1-dimethyl-4-diphenylacetoxypiperidinium iodide (4-DAMP) in wild-type mice. Collectively, our data indicate a pro-inflammatory role for the M3 receptor in cigarette smoke-induced neutrophilia and cytokine release, yet an anti-inflammatory role for M1 and M2 receptors. Inhibition of the muscarinic M3 receptor prevents inflammation in response to cigarette smoke exposure in mice http://ow.ly/p7UdG}, issn = {0903-1936}, URL = {//www.qdcxjkg.com/content/42/6/1677}, eprint = {//www.qdcxjkg.com/content/42/6/1677.full.pdf}, journal = {European Respiratory Journal} }