RT Journal第SR电子T1尿生物标志物用于严重阻塞性睡眠呼吸暂停患者：Lipocalin型前列腺素D合酶JF欧洲呼吸杂志Jo EUR Respir J FD欧洲呼吸学会SP 1563 OP 1574 Do 10.1183 / 09031936.00133512 VO 42是6 A1 Chihara，Yuichi188bet官网地址A1 Chin，Kazuo A1 Aritake，Kosuke A1 Harada，Yoshiro A1 Murase，Kimihiko A1 Yoshimura，Chikara A1 Hitomi，TakeFumi A1 oga，Toru A1 Mishima，Michiaki A1 Urade，Yoshihiro YR 2013 UL HTTP：//ERJ.Errate据报道，COMSTRACT AB脂素型前列腺素D合酶（L-PGDS），其负责前列腺素D2的生物合成，与心血管疾病和睡眠调节密切相关。本研究旨在测试L-PGDS水平是鉴定阻塞性睡眠呼吸暂停患者的有用标记的假设。在这项前瞻性研究中注册了64项受试者。在早晨测量L-PGDS的尿浓度。每6例患者中的25例每4小时进行测量。通过反应性高血肿周围动脉调调指数评估内皮功能。L-PGDS浓度的昼夜变异具有显着的时间依赖性波动（P = 0.0002）。L-PGDS在具有严重阻塞性睡眠呼吸暂停的受试者中较高（每毫克/毫克肌酐，N = 23）的受试者比对照受试者（262.1ng /毫克肌酸酐，n = 16; p = 0.004）和其中 moderate obstructive sleep apnoea (371.7 ng per mg of creatinine, n = 25; p = 0.0008). After 2 days of continuous positive airway pressure treatment, L-PGDS concentrations in severe obstructive sleep apnoea subjects (n = 12) decreased significantly (p = 0.02) to levels present in control subjects whereas endothelial function did not change significantly. Morning urinary L-PGDS concentrations had significant correlations with the apnoea/hypopnoea index (R2 = 13.9%) and serum high-density lipoprotein cholesterol (R2 = 6.2%), but not with sleepiness. Urinary L-PGDS might be a moderately useful marker to identify patients with severe obstructive sleep apnoea. Urinary lipocalin-type prostaglandin D synthase might be a moderately useful marker to identify patients with severe OSA http://ow.ly/pBuac