TY - T1的严重obstru尿液生物标志物ctive sleep apnoea patients: lipocalin-type prostaglandin D synthase JF - European Respiratory Journal JO - Eur Respir J SP - 1563 LP - 1574 DO - 10.1183/09031936.00133512 VL - 42 IS - 6 AU - Chihara, Yuichi AU - Chin, Kazuo AU - Aritake, Kosuke AU - Harada, Yuka AU - Toyama, Yoshiro AU - Murase, Kimihiko AU - Yoshimura, Chikara AU - Hitomi, Takefumi AU - Oga, Toru AU - Mishima, Michiaki AU - Urade, Yoshihiro Y1 - 2013/12/01 UR - //www.qdcxjkg.com/content/42/6/1563.abstract N2 - Lipocalin-type prostaglandin D synthase (L-PGDS), which is responsible for the biosynthesis of prostaglandin D2, has been reported to have a close connection with cardiovascular disease and sleep regulation. This study aimed to test the hypothesis that the L-PGDS level is a useful marker to identify patients with obstructive sleep apnoea. 64 subjects were enrolled in this prospective study. Urinary concentrations of L-PGDS were measured in the morning. Measurements were made every 4 h in 25 of the 64 patients. Endothelial function was assessed by the reactive hyperaemia peripheral arterial tone index. Circadian variations in L-PGDS concentrations had a significant time-dependent fluctuation (p = 0.0002). L-PGDS was higher in the subjects with severe obstructive sleep apnoea (median 784.7 ng per mg of creatinine, n = 23) than in control subjects (262.1 ng per mg of creatinine, n = 16; p = 0.004) and in those with moderate obstructive sleep apnoea (371.7 ng per mg of creatinine, n = 25; p = 0.0008). After 2 days of continuous positive airway pressure treatment, L-PGDS concentrations in severe obstructive sleep apnoea subjects (n = 12) decreased significantly (p = 0.02) to levels present in control subjects whereas endothelial function did not change significantly. Morning urinary L-PGDS concentrations had significant correlations with the apnoea/hypopnoea index (R2 = 13.9%) and serum high-density lipoprotein cholesterol (R2 = 6.2%), but not with sleepiness. Urinary L-PGDS might be a moderately useful marker to identify patients with severe obstructive sleep apnoea. Urinary lipocalin-type prostaglandin D synthase might be a moderately useful marker to identify patients with severe OSA http://ow.ly/pBuac ER -