PT-日记文章Au -Blanco，Isabel au -Santos，Salud au -Gea，JoaqímAu -Güell，Rosa au -Torres，Ferran Au -Gimeno -Santos，Elena Au -Rodriguez，Rodriguez，Rodriguez，diego a.au -au -au -au -au -au -jordi au- jordi au-Gómez, Begona AU - Roca, Josep AU - Barberà, Joan Albert TI - Sildenafil to improve respiratory rehabilitation outcomes in COPD: a controlled trial AID - 10.1183/09031936.00176312 DP - 2013 Oct 01 TA - European Respiratory Journal PG - 982--992 VI-42 IP -4 4099 -http：//www.qdcxjkg.com/content/42/4/982.short 4100 -http：//www.qdcxjkg.com/content.com/content/42/42/4/4/982.full呼吸J2013 10月1日;42 AB-肺动脉高压是目前尚无既定药理治疗的慢性阻塞性肺疾病（COPD）的严重并发症。这项研究旨在评估西地那非的伴随治疗是否会增强COPD患者肺部康复的结果和肺动脉压升高（PAP）。在这次双盲，随机对照试验中，患者每天三次接受20毫克西地那非或安慰剂，并接受肺部康复3个月。主要的终点是在恒定工作率下的周期耐力时间中的增益。次要终点包括在增量运动测试，步行6分钟的距离和生活质量中的表现。63例严重COPD患者和中度增加的PAP患者是随机分配的。 Cycle endurance time increased by 149 s (95% CI 26–518 s) in the sildenafil group and by 169 s (95% CI 0–768 s) in the placebo group (median change difference -7 s, 95% CI -540–244 s; p=0.77). Gains in the incremental exercise test, 6-min walk distance and quality of life at the end of the study did not differ between groups. Measurements of arterial oxygenation and adverse events were similar in both groups. In patients with severe COPD and moderately increased PAP, concomitant treatment with sildenafil does not improve the results of pulmonary rehabilitation in exercise tolerance. Sildenafil did not improve respiratory rehabilitation outcomes in patients with severe COPD and moderately increased PAP http://ow.ly/lh7cb