TY-JUR T1 - 治疗药物管理:是多药抗性结核治疗的未来吗?JF - 欧洲呼吸杂志Jo - Eur Respir J SP - 1449 LP - 1453 Do - 10.1183 / 09031936.00073213 VL - 42是 - 6 Au - Srivastava,Shashikant Au - Peloquin,Charles A. Au - Sotgiu,Giovanni Au - Migliori,Giovanni BattiStaY1 - 2013/12/01 UR - //www.qdcxjkg.com/content/42/6/1449.abstract n2 - 多rrug-和广泛的耐药性(m / xdr)结核(tb)是新兴的公共卫生担心[1,2]。2011年,世界卫生组织(世卫组织)估计全球TB的1200万次普遍存在的案件,这相当于每100 000人口170例,其中估计的630万个病例受MDR分枝杆菌菌株的影响[3​​]。在新诊断的患者中,〜3.7%受到MDR-TB菌株的感染,但令人担忧的事实是,一些前苏联国家新案件中MDR-TB的患病率超过30%[4,5],XDR-TB有已在84个国家确定,XDR-TB模式的MDR-TB病例的平均比例为9.0%[3]。进一步加入问题是“完全耐药”TB [6,7]的报告,目前无法通过世卫组织识别的术语[8,9]。与规定的规定相比,耐药性TB的耐药性更昂贵,更具毒性对于药物易感结核病,目前需要2年的治疗[10]。治疗MDR-TB病例的每位患者的成本是令人难以置信的高[11,12],尽管有国际公共卫生努力,但治疗结果并非非常​​有前途[13-15]。 Diel et al. [16] showed that direct treatment-related costs of MDR-TB patients can amount to €52 259 in Germany (table 1).View this table:In this windowIn a new windowTable 1– Direct costs of multidrug-resistant tuberculosis (MDR-TB) therapy in a European low-income country In the largest MDR-TB cohort analysed to date [13] the proportion of cases treated successfully was 62%, with 7% failing or relapsing, 9% dying and 17% defaulting; in the XDR-TB subgroup 40% achieved treatment success, 22% failed treatment or relapsed, whereas 15% died and 16% defaulted [14, 15].In this issue of the … ER -