@article {Orsmark-Pietras65作者= {Orsmark-Pietras,克里斯蒂娜和詹姆斯,安娜和Konradsen,乔恩·r·Nordlund, Bj {\“o} rn和S {\“o} derh{\”}会,Cilla Pulkkinen,城镇和Pedroletti,克利斯朵夫和Daham Kameran Kupczyk, Maciek和达尔{\ ' e n}, barbroandreasson·凯雷,胡和达尔{\ ' e n}, Sven-Erik Hedlin,格尼拉和梅尔·{\ ' e n}, Erik}, title ={苦味受体的转录组分析揭示了upregulation严重哮喘患者},体积={42}={1},页面= {65 - 78}= {2013},doi ={10.1183/09031936.00077712},出版商={欧洲呼吸学会},文摘={严重的儿童哮喘的原因知之甚少。188bet官网地址我们的目的是定义全局的基因表达模式在儿童严重therapy-resistant和控制哮喘。白细胞是孤立的和全球转录组剖面特征使用人类基因Affymetrix圣1.0芯片在儿童严重哮喘(n = 17),控制哮喘(n = 19)和健康对照组(n = 18)。受体表达在白细胞分离研究分数从成人哮喘(n = 12)。总的来说,1378个基因表达有差异之间严重/控制儿童哮喘和控制。三个大大丰富了《京都议定书》为代表的基因和基因组途径是百科全书:自然杀伤细胞介导细胞毒性(调节控制哮喘);严重哮喘N-glycan生物合成(下调);和苦味受体转导(TAS2Rs)在严重哮喘(调节)。定量PCR实验证实upregulation TAS2Rs严重哮喘患者。TAS2R表达在白细胞复制从成人哮喘患者,其中TAS2R受体激动剂也抑制LPS-induced细胞因子释放。 Significant correlations between expression of TAS2Rs and clinical markers of asthma severity were found in both adults and children. In conclusion, specific gene expression patterns were observed in children with severe, therapy-resistant asthma. The increased expression of bronchodilatory TAS2Rs suggests a new target for the treatment of asthma.}, issn = {0903-1936}, URL = {//www.qdcxjkg.com/content/42/1/65}, eprint = {//www.qdcxjkg.com/content/42/1/65.full.pdf}, journal = {European Respiratory Journal} }