TY -的T1 azit的随机对照试验hromycin in smokers with asthma JF - European Respiratory Journal JO - Eur Respir J SP - 1412 LP - 1415 DO - 10.1183/09031936.00093913 VL - 42 IS - 5 AU - Cameron, Euan J. AU - Chaudhuri, Rekha AU - Mair, Frances AU - McSharry, Charles AU - Greenlaw, Nicola AU - Weir, Christopher J. AU - Jolly, Lisa AU - Donnelly, Iona AU - Gallacher, Katie AU - Morrison, Deborah AU - Spears, Mark AU - Evans, Tom J. AU - Anderson, Kenneth AU - Thomson, Neil C. Y1 - 2013/11/01 UR - //www.qdcxjkg.com/content/42/5/1412.abstract N2 - To the Editor:Smokers with asthma have poor symptom control, accelerated decline in lung function and an attenuated response to corticosteroids compared to nonsmokers with asthma [1]. There is an unmet need for alternative or additional drugs for smokers with asthma who are unable to stop smoking [2]. Macrolide antibiotics have anti-inflammatory activity [3] and in clinical studies there is good evidence for efficacy in the treatment of diffuse pan-bronchiolitis and cystic fibrosis, as well as in preventing chronic rejection after lung transplantation [4, 5]. In asthma, chronic treatment is associated with a reduction in bronchial hyperreactivity in mild-to-moderate asthma [6] and in exacerbation rates in non-eosinophilic severe asthma [7]. To date, no studies have examined the efficacy of macrolide antibiotics exclusively in current smokers with asthma.A randomised double-blind parallel-group trial compared azithromycin, 250 mg per day, with placebo for 12 weeks. All subjects were aged 18–70 years, were current smokers (≥5 pack-years history) with chronic asthma (>1 year duration; defined by international criteria [8]) and had to be free of exacerbation and respiratory tract infection for a minimum 6-week period prior to randomisation. A baseline visit was performed following a 4-week run-in period on inhaled corticosteroid (ICS) therapy equivalent to 400 μg beclometasone ± a long-acting β2-agonist (LABA). Ethical approval was obtained and all subjects provided written informed consent. Study visits were performed at 4, 8 and 12 weeks. Clinic visit peak expiratory flow (PEF) after 12 weeks treatment was the primary outcome measure. A sample size of 68 … ER -