TY - T1的嗜酸性细支气管炎:是new syndrome? JF - European Respiratory Journal JO - Eur Respir J SP - 1012 LP - 1013 DO - 10.1183/09031936.00041813 VL - 41 IS - 5 AU - Poletti, Venerino Y1 - 2013/05/01 UR - //www.qdcxjkg.com/content/41/5/1012.abstract N2 - Identification of new diseases or a cluster (syndrome) of disorders with very similar pathological, radiological and clinical aspects, even sharing common pathogenic steps, is an important fact to build up the scientific soul of the complex and intriguing art called medicine. In this issue of the European Respiratory Journal, a new distinct syndrome, hypereosinophilic obliterative bronchiolitis, is described by Cordier et al. [1]. This syndrome is defined by: 1) a blood eosinophil cell count >1 G·L−1 and/or a bronchoalveolar lavage (BAL) eosinophil differential cell count >25%; 2) persistent airflow obstruction on lung function tests not modifiable after 4–6 weeks of inhaled corticosteroid therapy (2000 μg·day−1 of beclometasone or equivalent); and 3) a lung biopsy showing inflammatory bronchiolitis with prominent bronchiolar wall infiltration by eosinophils and/or characteristic direct high-resolution computed tomography (HRCT) features of bronchiolitis (poorly defined centrilobular nodules, branching opacities and tree-in-bud pattern). The first impression that a cursory clinician and/or pathologist may have, going swiftly through this list of criteria, is that “we are dealing with a severe and persistent form of asthma”. In chronic asthma the obstructive impairment becomes fixed and not modifiable, at least not easily, with steroids or bronchodilators. In chronic asthma eosinophils in lung tissue and blood may be constantly increased and HRCT scans show abnormalities in between 68% and 90% of patients (bronchial wall thickening and narrowing … ER -