TY -JOR T1-肺癌患者的支气管定殖：一项前瞻性研究JF-欧洲呼吸杂志JO -EUR RESSIR J SP -220 LP -220 LP -229 DO -10.1183/09031936.00062212 VL -42Lepage, Benoît AU - Hermant, Christophe AU - Plat, Gavin AU - Phelippeau, Michael AU - Bigay-Game, Laurence AU - Lozano, Stéphanie AU - Guibert, Nicolas AU - Segonds, Christine AU - Mallard, Valérie AU - Augustin, NathalieAu -didier，Alain au -Mazieres，Julien Y1-2013/07/01 Ur -http：//www.qdcxjkg.com/content/42/1/1/220.Abstract.Abstract.Abstract N2-肺癌患者经常报道支气管殖民，并且对治疗管理和预后有潜在的影响。我们的目的是在诊断出肺癌时前瞻性地定义患者支气管定殖的患病率和性质。210例肺癌连续患者进行了针对肺癌的柔性支气管镜检查。分析了细菌，分枝杆菌和真菌定植的类型和频率，并与患者和肿瘤的特征相关。在48.1％的样品中发现了潜在的病原体：主要是革兰氏阴性杆菌大肠杆菌（8.1％），流感嗜血杆菌（4.3％）和肠杆菌属。（2.4％）;革兰氏阳性球菌，葡萄球菌属。（12.9％）和肺炎链球菌（3.3％）； atypical mycobacteria (2.9%); Candida albicans (42.9%); and Aspergillus fumigatus (6.2%). Aged patients (p=0.02) with chronic obstructive pulmonary disease (p=0.008) were significantly more frequently colonised; however, tumour stage, atelectasis, bronchial stenosis and abnormalities of chest radiography were not associated with a higher rate of colonisation. Squamous cell carcinoma tended to be more frequently colonised than other histological subtypes. Airway colonisation was reported in almost half of patients presenting with lung cancer, mainly in fragile patients, and was significantly associated with worse survival (p=0.005). Analysing colonisation status of patients at the time of diagnosis may help improve the management of lung cancer. ER -