PT-日记文章Au -Kager，Liesbeth M.Au -de Boer，J。Daanau -Bresser，Paul Au -van der au -van der Zee，Jaring S. Au -Zeerleder -Zeerleder，Sacha Au -Meijers -Meijers，Joost C.M.AU - van 't Veer, Cornelis AU - van der Poll, Tom TI - Intrabronchial activated protein C enhances lipopolysaccharide-induced pulmonary responses AID - 10.1183/09031936.00057112 DP - 2013 Jul 01 TA - European Respiratory Journal PG - 188--197 VI -42 IP -1 4099 -http：//www.qdcxjkg.com/content/42/1/188.short 4100 -http：//www.qdcxjkg.com/content.com/content/42/42/1/1/188.fullJ2013 7月1日;42 AB-静脉注射活化蛋白C（APC）抑制人类和动物肺的凝血和炎症。对啮齿动物的研究表明，APC的直接肺内递送还会发挥抗凝剂和抗炎作用。研究了人类支气管肺泡空间中重组人（RH）APC对脂多糖（LPS）诱导的止血和炎症改变的影响。八名受试者通过支气管镜通过临时滴注RHAPC接受了RHAPC，而在对侧子段中接受了盐水；所有受试者均在同一肺部疾病中用LPS双侧挑战。另外四名受试者接受了RHAPC（75μg），在对侧子段中用盐水作为对照，而双侧则用盐水“挑战”。 After 6 h a bronchoalveolar lavage was performed and coagulation and inflammatory parameters were measured. rhAPC enhanced LPS-induced coagulation activation in the bronchoalveolar space, when compared with the control side. In addition, rhAPC amplified LPS-induced pro-inflammatory responses, as indicated by higher concentrations of cytokines and chemokines. rhAPC alone did not have procoagulant or pro-inflammatory effects. Locally administered rhAPC has unexpected procoagulant and pro-inflammatory effects in LPS-challenged lung subsegments. These data argue against a role for intrapulmonary delivery of rhAPC as a treatment strategy for lung inflammatory disorders in humans.