@Article {Kager188，作者= {Kager，Liesbeth M.和De Boer，J. Daan和Bresterer，Paul和Van der Zee，Jaring S.和Zeerleder，Sacha和Meijers，Joost C.M.和van {\ textquoteright} tveer，cornelis和van der poll，tom}，标题= {Intrabronchial活化蛋白c增强脂多糖诱导的肺响应}，体积= {42}，number = {1}，页面= {188--197}，年= {2013}，发行商= {10.1183 / 09031936.00057112}，出版商= {欧洲呼吸学社会}，摘要= 188bet官网地址{静脉内施用活化蛋白C（APC）抑制人和动物肺中的凝血和炎症。啮齿动物的研究表明，APC的直接肺递送也施加抗凝血和抗炎作用。研究了对重组人（RH）APC对人类支气管肺泡空间的血液多糖（LPS）诱导的血压和炎性改变的影响。八次受试者通过支气管镜通过Intrabronchial灌输接受rhapc，而在对侧沉淀受试者中受到盐水;所有受试者在同一肺部次级的LPS双侧挑战。另外四个受试者接受rhapc（75μg），盐水作为对侧底段的控制，而它们是双边{\ textquotedblleft}挑战{\ textquotedblright}用盐水。6小时后，进行支气管肺泡灌洗，并测量凝血和炎症参数。与对照侧相比，rhAPC增强了支气管肺泡空间中的LPS诱导的凝血活化。 In addition, rhAPC amplified LPS-induced pro-inflammatory responses, as indicated by higher concentrations of cytokines and chemokines. rhAPC alone did not have procoagulant or pro-inflammatory effects. Locally administered rhAPC has unexpected procoagulant and pro-inflammatory effects in LPS-challenged lung subsegments. These data argue against a role for intrapulmonary delivery of rhAPC as a treatment strategy for lung inflammatory disorders in humans.}, issn = {0903-1936}, URL = {//www.qdcxjkg.com/content/42/1/188}, eprint = {//www.qdcxjkg.com/content/42/1/188.full.pdf}, journal = {European Respiratory Journal} }