慢性阻塞性肺病和空中旅行:低氧高空模拟试验能预测飞行中呼吸道症状吗?JF - European Respiratory Journal JO - Eur Respir J SP - 1216 LP - 1223 DO - 10.1183/09031936.00157112 VL - 42 IS - 5 AU - Edvardsen, Anne AU - Ryg, Morten AU - Akerø， Aina AU - Christensen, Carl Christian AU - Skjønsberg，olh . Y1 - 2013/11/01 UR - //www.qdcxjkg.com/content/42/5/1216.abstract N2 -飞机客舱压力降低可能导致慢性阻塞性肺疾病(COPD)患者出现明显的低氧血症和呼吸道症状。本研究评估了模拟海拔2438 m的低氧海拔模拟试验(hypoxia altitude simulation testing，简称HAST)中获得的低氧血症与航空旅行中呼吸道症状报告是否存在相关性。82例中重度COPD患者接受了航空旅行问卷调查。对有和没有飞行中呼吸道症状的受试者在HAST (PaO2HAST)期间的动脉氧张力进行了比较。全港市民在“全港市民谘询会”后一年内回答相同的问卷。PaO2HAST平均值(±sd)为6.3±0.6 kPa, 62例(76%)患者PaO2HAST <6.6 kPa。38例(46%)患者在航空旅行期间出现呼吸道症状。PaO2HAST在有和无机上呼吸道症状的两组间无差异(6.3±0.7 kPa和6.3±0.6 kPa); p=0.926). 54 (66%) patients travelled by air after the HAST, and patients equipped with supplemental oxygen (n=23, 43%) reported less respiratory symptoms when flying with than those without such treatment (four (17%) versus 11 (48%) patients; p=0.039). In conclusion, no difference in PaO2HAST was found between COPD patients with and without respiratory symptoms during air travel. Hypoxia-altitude simulation testing does not predict in-flight respiratory symptoms in COPD patients http://ow.ly/nUCtF ER -