TY -的T1 unclass患病率和预后ifiable interstitial lung disease JF - European Respiratory Journal JO - Eur Respir J SP - 750 LP - 757 DO - 10.1183/09031936.00131912 VL - 42 IS - 3 AU - Ryerson, Christopher J. AU - Urbania, Thomas H. AU - Richeldi, Luca AU - Mooney, Joshua J. AU - Lee, Joyce S. AU - Jones, Kirk D. AU - Elicker, Brett M. AU - Koth, Laura L. AU - King, Talmadge E. AU - Wolters, Paul J. AU - Collard, Harold R. Y1 - 2013/09/01 UR - //www.qdcxjkg.com/content/42/3/750.abstract N2 - The aim of this study was to determine the prevalence, characteristics and outcomes of patients with unclassifiable interstitial lung disease (ILD) and to develop a simple method of predicting disease behaviour. Unclassifiable ILD patients were identified from an ongoing longitudinal cohort. Unclassifiable ILD was diagnosed after a multidisciplinary review did not secure a specific ILD diagnosis. Clinical characteristics and outcomes were compared with idiopathic pulmonary fibrosis (IPF) and non-IPF ILDs. Independent predictors of mortality were determined using Cox proportional-hazards analysis to identify subgroups with distinct disease behaviour. Unclassifiable ILD was diagnosed in 10% of the ILD cohort (132 out of 1370 patients). The most common reason for being unclassifiable was missing histopathological assessment due to a high risk of surgical lung biopsy. Demographic and physiological features of unclassifiable ILD were intermediate between IPF and non-IPF disease controls. Unclassifiable ILD had longer survival rates when compared to IPF on adjusted analysis (hazard ratio 0.62, p = 0.04) and similar survival compared to non-IPF ILDs (hazard ratio 1.54, p = 0.12). Independent predictors of survival in unclassifiable ILD included diffusion capacity of the lung for carbon monoxide (p = 0.001) and a radiological fibrosis score (p = 0.02). Unclassifiable ILD represents approximately 10% of ILD cases and has a heterogeneous clinical course, which can be predicted using clinical and radiological variables. Unclassifiable ILD has a heterogeneous clinical course that can be predicted using clinical and radiological variables http://ow.ly/mdjwg ER -