@article {Mwenge360，作者= {Mwenge, Gimbada B.和Rombaux, Philippe和Dury, Myriam和Lengel{e}， Beno}t和Rodenstein, Daniel}，标题={针对阻塞性睡眠呼吸暂停的舌下神经刺激:1年试点研究}，卷={41}，数={2}，页={360—367}，年= {2013}，doi ={10.1183/09031936.00042412}，出版者={欧洲呼吸协会}，摘要={持续气道正压通气(CPAP)是一种有效但繁琐的阻塞性睡眠呼吸暂停(OSA)治疗方法。188bet官网地址不服从的患者需要替代疗法。我们研究了一种舌神经刺激方法:使用aura6000{\texttrademark}系统的舌下神经刺激(THN)靶向治疗。位于第十二神经主干周围的多接触电极与植入的脉冲发生器相连，刺激神经的各个节段，激活扩张器肌肉。主要目的是在3个月时改善经多导睡眠测定的呼吸暂停/垂体指数(AHI)，并在治疗12个月后保持改善。14例手术患者中有13例成功植入。12个月时，AHI从45{\textpm}18下降到21{\textpm}17，下降了53 % (p <0.001)。4 %的氧饱和度指数从29{\textpm}20下降到15{\textpm}16，唤醒指数从37{\textpm}13下降到25{\textpm}14，两者p <0.001。Epworth嗜睡量表由11{\textpm}7降至8{\textpm}4 (p=0.09)。 THN was neither painful nor awakened patients, who all complied with therapy. There were two transient tongue paresis. The present study represents the longest study of any hypoglossal neurostimulation reported to date. We conclude that THN is safe and effective to treat OSA in patients not compliant with CPAP.}, issn = {0903-1936}, URL = {//www.qdcxjkg.com/content/41/2/360}, eprint = {//www.qdcxjkg.com/content/41/2/360.full.pdf}, journal = {European Respiratory Journal} }