RT期刊文章SR电子T1继续其他的使用ous positive airway pressure reduces airway reactivity in adults with asthma JF European Respiratory Journal JO Eur Respir J FD European Respiratory Society SP 317 OP 322 DO 10.1183/09031936.00059712 VO 41 IS 2 A1 Busk, Michael A1 Busk, Nancy A1 Puntenney, Paula A1 Hutchins, Janet A1 Yu, Zhangsheng A1 Gunst, Susan J. A1 Tepper, Robert S. YR 2013 UL //www.qdcxjkg.com/content/41/2/317.abstract AB Asthma is characterised by airway hyperreactivity, which is primarily treated with β-adrenergic bronchodilators and anti-inflammatory agents. However, mechanical strain during breathing is an important modulator of airway responsiveness and we have previously demonstrated in animal models that continuous positive airway pressure (CPAP) resulted in lower in vivo airway reactivity. We now evaluated whether using nocturnal CPAP decreased airway reactivity in clinically-stable adults with asthma. Adults with stable asthma and normal spirometry used nocturnal CPAP (8–10 cmH2O) or sham treatment (0–2 cmH2O) for 7 days. Spirometry and bronchial challenges were obtained before and after treatment. The primary outcome was the provocative concentration of methacholine causing a 20% fall in forced expiratory volume in 1 s (PC20). The CPAP group (n=16) had a significant decrease in airway reactivity (change in (Δ)logPC20 0.406, p<0.0017) while the sham group (n=9) had no significant change in airway reactivity (ΔlogPC20 0.003, p=0.9850). There was a significant difference in the change in airway reactivity for the CPAP versus the sham group (ΔlogPC20 0.41, p<0.043). Our findings indicate that chronic mechanical strain of the lungs produced using nocturnal CPAP for 7 days reduced airway reactivity in clinically stable asthmatics. Future studies of longer duration are required to determine whether CPAP can also decrease asthma symptoms and/or medication usage.