TY - T1的健康状况的比较分数with MRC grades in COPD: implications for the GOLD 2011 classification JF - European Respiratory Journal JO - Eur Respir J SP - 647 LP - 654 DO - 10.1183/09031936.00125612 VL - 42 IS - 3 AU - Jones, Paul W. AU - Adamek, Lukasz AU - Nadeau, Gilbert AU - Banik, Norbert Y1 - 2013/09/01 UR - //www.qdcxjkg.com/content/42/3/647.abstract N2 - The 2011 Global Initiative for Chronic Obstructive Lung Disease (GOLD) strategy document recommends assessment of chronic obstructive pulmonary disease (COPD) using symptoms and future exacerbation risk, employing two score cut-points: COPD Assessment Test (CAT) score ≥10 or modified Medical Research Council dyspnoea scale (mMRC) grade ≥2. To explore the equivalence of these two symptom cut-points, the relationship between the CAT and the mMRC and St George's Respiratory Questionnaire (SGRQ), the Short-form Health Survey and the Functional Assessment of Chronic Illness Therapy Fatigue scores were retrospectively analysed using a primary care dataset. Data from 1817 patients (mean±sd forced expiratory volume in 1 s 1.6±0.6 L) showed a significant association between mMRC grades and all health status scores (ANOVA p<0.0001). mMRC grade 1 was associated with significant levels of health status impairment (SGRQ 39.4±15.5 and CAT 15.7±7.0); even patients with mMRC grade 0 had modestly elevated scores (SGRQ 28.5±15.1 and CAT 11.7±6.8). An mMRC grading ≥2 categorised 57.2% patients with low symptom (groups A and C) versus 17.2% with the CAT. Using the mMRC cut-point (≥1) resulted in similar GOLD group categorisations as the CAT (18.9%). The mMRC showed a clear relationship with health status scores; even low mMRC grades were associated with health status impairment. Cut-points of mMRC grade ≥1 and CAT score ≥10 were approximately equivalent in determining low-symptom patients. The GOLD assessment framework may require refinement. Low mMRC grades were linked with significantly impaired health; the GOLD COPD assessment framework may need refinement http://ow.ly/mAuiS ER -