TY - T1的特性、稳定性和outcomes of the 2011 GOLD COPD groups in the ECLIPSE cohort JF - European Respiratory Journal JO - Eur Respir J SP - 636 LP - 646 DO - 10.1183/09031936.00195212 VL - 42 IS - 3 AU - Agusti, Alvar AU - Edwards, Lisa D. AU - Celli, Bartolomé AU - MacNee, William AU - Calverley, Peter M. A. AU - Müllerova, Hana AU - Lomas, David A. AU - Wouters, Emiel AU - Bakke, Per AU - Rennard, Steve AU - Crim, Courtney AU - Miller, Bruce E. AU - Coxson, Harvey O. AU - Yates, Julie C. AU - Tal-Singer, Ruth AU - Vestbo, Jørgen Y1 - 2013/09/01 UR - //www.qdcxjkg.com/content/42/3/636.abstract N2 - The 2011 Global Initiative for Chronic Obstructive Lung Disease (GOLD) classifies patients with chronic obstructive pulmonary disease (COPD) into four groups (A to D). We explored the characteristics, stability and relationship to outcomes of these groups within the ECLIPSE study (Evaluation of COPD Longitudinally to Identify Predictive Surrogate End-points) (n = 2101). Main results showed that: 1) these groups differed in several clinical, functional, imaging and biological characteristics in addition to those used for their own definition; 2) A and D groups were relatively stable over time, whereas groups B and C showed more temporal variability; 3) the risk of exacerbation over 3 years increased progressively from A to D, whereas that of hospitalisation and mortality were lowest in A, highest in D and intermediate and similar in B and C, despite the former having milder airflow limitation. The prevalence of comorbidities and persistent systemic inflammation were highest in group B. The different longitudinal behaviour of group A versus B and C versus D (each pair with similar forced expiratory volume in1 s (FEV1) values supports the 2011 GOLD proposal of assessing COPD patients by more than FEV1 only. However the assumption that symptoms do not equate to risk appears to be naïve, as groups B and C carry equally poor clinical outcomes, though for different reasons. Exploring distribution, characteristics, temporal stability and relationship with 2011 GOLD group outcomes in ECLIPSE http://ow.ly/mjJ8p ER -