作者@article {Agusti636 = {Agusti、乙烯树脂和Edwards, Lisa D. and Celli, Bartolom{\'e} and MacNee, William and Calverley, Peter M. A. and M{\"u}llerova, Hana and Lomas, David A. and Wouters, Emiel and Bakke, Per and Rennard, Steve and Crim, Courtney and Miller, Bruce E. and Coxson, Harvey O. and Yates, Julie C. and Tal-Singer, Ruth and Vestbo, J{\o}rgen}, title = {Characteristics, stability and outcomes of the 2011 GOLD COPD groups in the ECLIPSE cohort}, volume = {42}, number = {3}, pages = {636--646}, year = {2013}, doi = {10.1183/09031936.00195212}, publisher = {European Respiratory Society}, abstract = {The 2011 Global Initiative for Chronic Obstructive Lung Disease (GOLD) classifies patients with chronic obstructive pulmonary disease (COPD) into four groups (A to D). We explored the characteristics, stability and relationship to outcomes of these groups within the ECLIPSE study (Evaluation of COPD Longitudinally to Identify Predictive Surrogate End-points) (n = 2101). Main results showed that: 1) these groups differed in several clinical, functional, imaging and biological characteristics in addition to those used for their own definition; 2) A and D groups were relatively stable over time, whereas groups B and C showed more temporal variability; 3) the risk of exacerbation over 3 years increased progressively from A to D, whereas that of hospitalisation and mortality were lowest in A, highest in D and intermediate and similar in B and C, despite the former having milder airflow limitation. The prevalence of comorbidities and persistent systemic inflammation were highest in group B. The different longitudinal behaviour of group A versus B and C versus D (each pair with similar forced expiratory volume in1 s (FEV1) values supports the 2011 GOLD proposal of assessing COPD patients by more than FEV1 only. However the assumption that symptoms do not equate to risk appears to be na{\"\i}ve, as groups B and C carry equally poor clinical outcomes, though for different reasons. Exploring distribution, characteristics, temporal stability and relationship with 2011 GOLD group outcomes in ECLIPSE http://ow.ly/mjJ8p}, issn = {0903-1936}, URL = {//www.qdcxjkg.com/content/42/3/636}, eprint = {//www.qdcxjkg.com/content/42/3/636.full.pdf}, journal = {European Respiratory Journal} }