TY - T1的肺功能和痰特征预测断层表型和严重程度的慢性阻塞性肺病JF -欧洲呼吸杂志》乔和J SP - 626 LP - 635欧元——10.1183/09031936.00133112六世- 42 - 3盟Gianna Camiciottoli AU -弗朗西斯卡Bigazzi盟Matteo Paoletti AU -卢西亚Cestelli盟费德里科•Lavorini AU -马西莫Pistolesi Y1 - 2013/09/01 UR - //www.qdcxjkg.com/content/42/3/626.abstract N2 -气道阻塞和实质破坏构成表型和严重程度在慢性阻塞性肺疾病(COPD)。我们旨在预测,通过临床和肺功能数据,主要的类型和严重性病变定量评估计算机断层扫描(CT)。Airway wall thickness (AWT-Pi10) and percentage of lung area with X-ray attenuation values <-950 HU (%LAA-950) were measured in 100 (learning set) out of 473 COPD outpatients undergoing clinical and functional evaluation. Original CT measurements were translated by principal component analysis onto a plane with the novel coordinates CT1 and CT2, depending on the difference (prevalent mechanism of airflow limitation) and on the sum (severity) of AWT-Pi10 and %LAA-950, respectively. CT1 and CT2, estimated in the learning set by cross-validated models of clinical and functional variables, were used to classify 373 patients in the testing set. A model based on diffusing capacity of the lung for carbon monoxide, total lung capacity and purulent sputum predicted CT1 (r = 0.64; p<0.01). A model based on forced expiratory volume in 1 s/vital capacity, functional residual capacity and purulent sputum predicted CT2 (r = 0.77; p<0.01). Classification of patients in the testing set obtained by model-predicted CT1 and CT2 reflected, according to correlations with clinical and functional variables, both COPD phenotype and severity. Multivariate models based on pulmonary function variables and sputum purulence classify patients according to overall severity and predominant phenotype of COPD as assessed quantitatively by CT. Pulmonary function and sputum purulence models classify COPD patients by severity and phenotype as quantified by CT http://ow.ly/kyP6d ER -