A boorie, Raphael %A Cadranel, Jacques %A Guihot, Amélie %A Marcelin, Anne Geneviève %A Galicier, Lionel %A Couderc，人疱疹病毒(HHV)-8是一种致癌的伽玛疱疹病毒，于1994年首次在卡波西肉瘤病变中被描述。HHV-8参与了多中心Castleman病(MCD)和原发性积液淋巴瘤(PEL)的病理生理特征，这两种都是罕见的b细胞淋巴增生性疾病。hhv -8相关的肿瘤几乎只发生在免疫缺陷患者中，大多数是HIV感染患者。联合抗逆转录病毒疗法降低了卡波西肉瘤的发生率，但对MCD和PEL无效。hhv -8相关疾病经常表现为肺受累，这可能表明该疾病。肺卡波西肉瘤通常无症状，但可能需要特定的治疗。主要表现为皮肤或黏膜受累。典型的MCD患者表现为发热和淋巴结病变伴间质性肺疾病，无机会性感染。具体治疗可能是紧急的。 PEL provokes a febrile, lymphocytic-exudative pleural effusion, without a pleural mass on computed tomography scan. Rapid diagnosis prevents unnecessary examinations and leads to specific, rapid treatment. Therapy is complex, combining antiretroviral therapy and chemotherapy. HHV-8-related diseases frequently exhibit pulmonary involvement, which may indicate the disease http://ow.ly/ngJ65 %U //www.qdcxjkg.com/content/erj/42/4/1105.full.pdf