TY - T1的肺小动脉基因表达签名在特发性肺纤维化JF -欧洲呼吸杂志》乔和J SP - 1324 LP - 1330欧元——10.1183/09031936.0084112六世- 41 - 6盟尼娜·m·帕特尔非盟-史蒂文·m·Kawut盟Sanja Jelic AU -斯莱姆m . Arcasoy AU -大卫·J·莱德尔盟阿兰•c . Borczuk Y1 - 2013/06/01 UR - //www.qdcxjkg.com/content/41/6/1324.abstract N2 -三分之一的病人与特发性肺纤维化(IPF)开发肺动脉高压(PH-IPF),这是与死亡率增加有关。是否改变基因表达谱在肺血管之前的临床发病PH-IPF是未知的。我们比较基因表达在IPF患者的肺血管和没有PH值控制。肺小动脉孤立使用激光捕获显微解剖从16 IPF患者:8与酸碱(PH-IPF)和八个没有(NPH-IPF)和7个控制。从提取RNA探针制备、杂交Affymetrix Hu133 2.0 + genechips。生物研究分会数组工具和聪明才智通路分析软件被用于微阵列数据的分析。Univariate analysis revealed 255 genes that distinguished IPF arterioles from controls (p<0.001). Mediators of vascular smooth muscle and endothelial cell proliferation, Wnt signalling and apoptosis were differentially expressed in IPF arterioles. Unsupervised and supervised clustering analyses revealed similar gene expression in PH-IPF and NPH-IPF arterioles. The pulmonary arteriolar gene expression profile is similar in IPF patients with and without coexistent PH. Pathways involved in vascular proliferation and aberrant apoptosis, which may contribute to pulmonary vascular remodelling, are activated in IPF patients. ER -