PT -期刊文章盟内斯特太阳系AU -马里亚诺·Esperatti盟-圣地亚哥Ewig盟Arturo韦尔塔sncf托雷斯TI - AU -卡洛斯Agusti盟痰purulence-guided抗生素的使用在慢性阻塞性肺病加重病人的住院患者援助- DP - 2012年12月01 TA - 10.1183/09031936.00150211欧洲呼吸杂志》第六PG - 1344 - 1353 - 40 IP - 6 4099 - //www.qdcxjkg.com/content/40/6/1344.short 4100 - //www.qdcxjkg.com/content/40/6/1344.full所以欧元和J2012 12月01;40 AB -患者的慢性阻塞性肺疾病(COPD)急性加重需要住院治疗,痰脓与下呼吸道细菌有关。我们进行了前瞻性non-randomised介入试点研究应用抗生素治疗的痰purulence-guided战略和调查脓痰和生物标记物之间的关系。在住院患者急性加重的慢性阻塞性肺病抗生素限制那些有脓性痰。主要终点是住院期间治疗失败率。二级终端参数反映了短期和长期的结果。我们包括73名患者,34 non-purulent痰。没有观察到治疗失败标准差异(9% non-purulent脓性(p = 0.51)和10%)。血清c反应蛋白(CRP)是脓性组显著增加录取(11.6和5.3,p = 0.006),在第三天(2.7和1.2,p = 0.01)。血清原降钙素(PCT)之间的类似团体。 No differences were found in short-term outcomes. The exacerbation rate at 180 days was higher in the purulent group. These results support the hypothesis of performing a randomised trial using a sputum purulence-guided antibiotic treatment strategy in patients with acute exacerbations of COPD. CRP, but not PCT, may be a useful parameter to increase confidence of the absence of bacterial bronchial infection.