TY -的T1 -基因型MTBDR < em > sl < / em >性能在临床样本不同遗传背景JF -欧洲呼吸杂志》乔和J SP - 690 LP - 698欧元——六世- 40 10.1183/09031936.00164111 - 3盟Miotto保罗AU - Cabibbe,安德里亚·m . AU - Mantegani Paola AU - Borroni,埃盟——Fattorini, Lanfranco盟——TortoliEnrico AU - Migliori, Giovanni B. AU - Cirillo, Daniela M. Y1 - 2012/09/01 UR - //www.qdcxjkg.com/content/40/3/690.abstract N2 -我们评估基因型®MTBDRsl的性能(Hain Lifescience Nehren，我们将突变频率与不同的结核分枝杆菌基因型相关联。我们检测了175株菌株和59个临床标本，根据诊断准确性报告标准的建议解释结果。所有菌株均采用spoligotyping和mycobacterium Interspersed Repeats - variable Number of Tandem Repeats分型。MTBDRsl在检测临床分离株对氟喹诺酮类药物(FQ)、二线注射药物(SLID)和乙胺丁醇(EMB)耐药性方面的表现相似(特异性~ 99%，敏感性~ 70%，阳性预测值(PPV) ~ 99%)。59例呼吸道标本中，3例为“不确定”。FQs和EMB检测耐药的特异性相似，分别为100% (95% CI 92.7-100%)和100% (95% CI 83.9-100%)， PPV分别为100% (95% CI 64.6-100%)和100% (95% CI 87.9-100%)。slide检测的特异性为89.1% (95% CI 77.0-95.3%)， PPV为58.3% (95% CI 32.0-80.7%)。fq电阻检测的灵敏度为100% (95% CI 64.6-100%)，而滑枕和EMB的灵敏度分别为89.1% (95% CI 77.0-95.3%)和86.1% (95% CI 71.3-93.9%)。 We detected a significant association between mutations in the rrs gene and Beijing lineage. The MTBDRsl can be used to “rule in” extensively drug-resistant strains of tuberculosis in a high risk group; the low sensitivity and negative predicted value (NPV) make confirmation by conventional drug susceptibility testing mandatory when mutations are not identified. NPV for SLID is higher in Beijing strains, showing that the predictive values of the molecular tests are related to the genetic background. ER -