TY - T1的支气管扩张的影响,空气被困在囊性纤维化的生活质量和加重JF -欧洲呼吸杂志》乔欧元和J SP - 371 LP - 379 - 10.1183/09031936.00137612六世- 42是- 2非盟-珀蕾奥妮a . AU -展示,伊丽莎白M.W.J. AU - Caudri,她女儿非盟- Bos Aukje c . AU - Gonzalez-Graniel卡拉AU - Duivenvoorden,雨果·J . AU -范德由Els漫画,非盟- Quittner爆料称亚历山德拉•l . AU - TiddensA.W.M. Y1 - 2013/08/01 UR - //www.qdcxjkg.com/content/42/2/371.abstract N2 -囊性纤维化(CF)的主要特征是支气管扩张和胸部计算机断层扫描(CT)上的滞留空气。修订的囊性纤维化问卷呼吸症状量表(CFQ-R RSS)测量与健康相关的生活质量。为了验证支气管扩张、滞留空气和CFQ-R RSS作为结局指标，我们研究了肺加重的相关性和预测价值。CF患者(6-20岁)行CT、CFQ-R RSS及1年随访。使用CF-CT评分系统对支气管扩张和滞留空气进行评分。使用相关系数和逆向多变量模型来确定肺加重的预测因素。其中包括40名儿童和32名青少年。CF-CT支气管扩张(r = -0.38, p<0.001)和CF-CT滞留空气(r = -0.35, p = 0.003)与CFQ-R RSS相关。肺加重与支气管扩张相关(比率为1.10,95%可信区间1.02-1.19; p = 0.009), trapped air (rate ratio 1.02, 95% CI 1.00–1.05; p = 0.034) and CFQ-R RSS (rate ratio 0.95, 95% CI 0.91–0.98; p = 0.002). The CFQ-R RSS was an independent predictor of pulmonary exacerbations (rate ratio 0.96, 95% CI 0.94–0.97; p<0.001). Bronchiectasis, trapped air and CFQ-R RSS were associated with pulmonary exacerbations. The CFQ-R RSS was an independent predictor. This study further validated bronchiectasis, trapped air and CFQ-R RSS as outcome measures in CF. ER -