ty -jour t1 -copd：心肺疾病？JF-欧洲呼吸杂志JO -EUR RESSIR J SP -1241 LP -1243 DO -10.1183/09031936.00009413 VL -41 IS -6 AU -KAWUT -KAWUT，Steven M. Y1 -2013/06/06/01 UR -HTTP：//ERJ.ERSJOURJ.ERSJOURNALS.com/content/41/6/1241.Abstract N2-慢性阻塞性肺疾病（COPD）是由气流限制的存在来定义的，气流限制不完全可逆，但COPD涵盖了许多表型[1]。表型是遗传和环境相互作用的产物，其“环境”被广泛定义。对临床和其他定性和定量性状的系统测量和分析可能会完善COPD表型，其特征可以在不同疾病状态之间共享[2，3]。Han等。[4]将COPD中的临床表型定义为“疾病属性的单一或组合，这些疾病属性描述了患有COPD的个体与临床有意义的结果（症状，恶化，对治疗的反应，疾病进展或死亡的反应）时之间的差异。透明这种表型的识别不仅会促进结果预测和“个性化”治疗，而且还可以提高对关键生物学和机械疾病途径的理解。COPD的系统性影响导致在最近构建这些表型的努力中考虑了肺外疾病的表现。欧洲呼吸期刊的问题包含了COPD中侧重于心血管表型的两项最新研究之一[5，6]。赫德曼等人。 [5] have carefully evaluated the phenotype of severe pulmonary hypertension (PH) (mean pulmonary artery pressure ≥40 mmHg) in COPD (PH-COPD) in comparison to the mild–moderate PH phenotype in a prospective cohort of patients referred to a specialty centre over almost a decade [7]. Echocardiography, spirometry and lung computed tomography (CT) imaging were performed with standardised interpretation. 59 patients with severe PH-COPD were compared to 42 patients with mild–moderate PH-COPD, with complete follow-up in all. Patients with severe PH-COPD had worse oxygenation and a lower diffusing capacity for carbon monoxide (DLCO), but higher forced expiratory volume in 1 s (FEV1), forced vital capacity … ER -