Ty -jour t1-慢性铍疾病：硫唑嘌呤作为皮质类固醇治疗的可能替代方法JF-欧洲呼吸杂志JO -EUR RESSIR J SP -234 LP -234 LP -236 do -10.1183/09031936.000936.00095712- Gille, Thomas AU - Hervé, Aurélie AU - Bron, Camille AU - Lamberto, Christine AU - Valeyre, Dominique Y1 - 2013/01/01 UR - //www.qdcxjkg.com/content/41/1/234。它发生在囊性易感的个体中，最常见的是HLA-DPβ1（GLU69）多态性[1]。铍颗粒被缓慢地洗净，导致暴露于铍后很长时间的疾病延迟发作[2，3]。CBD的临床，放射学和病理学表现与曲折病非常相似。因此，正如Fireman等人报道的那样，误诊并不少见。[4]和Müller-Quernheim等。[5]。这些作者设法纠正了4-6％的患者将慢性结节病诊断为CBD的诊断，这要归功于对铍暴露的仔细回顾性筛查[4，5]。在CBD中，肺部受到弥漫性非持续性肉芽肿的损害，这可能导致肺部受损纤维化。美国铍病例注册处确定了CBD诊断的以下特定标准：铍暴露病史； relevant clinical and radiological signs (breathlessness, reduced pulmonary capacity and diffuse interstitial opacities); evidence of beryllium sensitisation with positive beryllium lymphocyte proliferation test in blood or in bronchoalveolar lavage (BAL); and histopathological features such as noncaseating granulomas or mononuclear tissue infiltration without any infection. Long-term prognosis of CBD is poor with a mortality rate ranging from 5.8% … ER -