TY - T1的呼出的气息分析诊断气喘的学龄前儿童JF -欧洲呼吸杂志》乔和J SP - 183 LP - 188欧元——10.1183/09031936.00122411六世- 41 - 1 AU - van de康德,金正日D.G.盟——效力过,•J.B.N.盟——Jobsis Quirijn AU -利马斯瓦AU -克拉森,酯M.M. AU - van der Sande琳达AU - van Schayck应该C.P. AU - de Jongste约翰c . AU - van Schooten弗雷德里克Jan AU - Derks Eduard盟——Dompeling爱德华盟——DallingaJan W. Y1 - 2013/01/01 UR - //www.qdcxjkg.com/content/41/1/183.abstract N2 -虽然喘息在学龄前儿童中很常见，但潜在的病理生理学尚未解开。呼气中的挥发性有机化合物(VOCs)可以作为早期喘息的非侵入性标记。我们旨在评估学龄前儿童VOC收集的可行性，并研究VOC谱是否可以区分有复发性喘息的儿童。我们纳入了(n=202)和(n=50)复发性喘息的儿童(平均(范围)3.3(1.9-4.5)岁。用气相色谱-飞行时间质谱法分析呼出的VOCs。VOC剖面采用方差分析(ANOVA)同步成分分析(ASCA)和稀疏逻辑回归(SLR)生成。98%的儿童可以收集呼出的气体。总共检测到913种不同的VOCs。利用ASCA预处理对年龄、性别和季节进行校正后，信噪比有所提高。 An SLR model with 28 VOCs correctly classified 83% of the children (84% sensitivity, 80% specificity). After six-fold cross-validation, 73% were correctly classified (79% sensitivity, 50% specificity). Assessment of VOCs in exhaled breath is feasible in young children. VOC profiles are able to distinguish children with and without recurrent wheeze with a reasonable accuracy. This proof of principle paves the way for additional research on VOCs in preschool wheezing. ER -