RT期刊文章SR电子T1循环纤维细胞的儿童和年轻人增加了肺动脉高压JF欧洲呼吸杂志JO EUR RESSIR J FD欧洲呼吸协会SP 104 OP 111 DO 10.1183/09031936.00072311 vo 39 IS 1 A1 A1 a1 a1 a1 a1 a1 a1 a1 a1 a1 a1 a1 a1 a1 a1 a1 a1 yeager，M188bet官网地址.E. a1 nguyen，c.M。A1 Belchenko，D.D。A1 Colvin，K.L。A1 Takatsuki，S。A1 Ivy，D.D。A1 Stenmark，K.R。YR 2012 UL //www.qdcxjkg.com/content/39/1/104.abstract ab gronic炎症是纤维增生性变化的重要组成部分，表征肺高血压血管疾病。纤维细胞在慢性炎症的环境中有助于组织重塑，包括肺动脉高压的动物模型（pH）。我们试图确定患有pH的儿童和年轻人的循环纤维细胞是否增加。研究了26个pH值和10个患有正常心脏解剖结构的人。通过流式细胞仪分析新鲜血液的纤维细胞表达CD45和Procollagen。 Fibrocyte numbers were correlated to clinical and haemodynamic parameters, and circulating CC chemokine ligand (CCL)2 and CXC chemokine ligand (CXCL)12 levels. We found an enrichment of circulating fibrocytes among those with PH. No differences in fibrocytes were observed among those with idiopathic versus secondary PH. Higher fibrocytes correlated to increasing mean pulmonary artery pressure and age, but not to length or type of treatment. Immunofluorescence analysis confirmed flow sorting specificity. Differences in plasma levels of CCL2 or CXCL12, which could mobilise fibrocytes from the bone marrow, were not found. We conclude that circulating fibrocytes are significantly increased in individuals with PH compared with controls. We speculate that these cells might play important roles in vascular remodelling in children and young adults with pulmonary hypertension.