PT -期刊文章盟做饭,AJ盟——Yuksel B非盟-桑普森,美联社AU -格里诺盟——价格,摩根富林明TI -半胱氨酰白三烯参与慢性肺部疾病早产儿DP - 1996年9月01 TA -欧洲呼吸杂志》第六PG - 1907 - 1912 - 9 IP - 9 4099 - //www.qdcxjkg.com/content/9/9/1907.short 4100 - //www.qdcxjkg.com/content/9/9/1907.full所以欧元和J1996 9月01;9 AB的病理生理学的早产儿慢性肺疾病(CLD)需要机械通气,长期补充氧气已经被很好的描述但潜在的机制并不清楚。我们的目的是测试假设多余半胱氨酰白三烯(LT)生产CLD的因素。我们比较LT生产和肺功能,在7个月大的时候,在9个早产儿CLD和八个控制没有CLD的婴儿。没有控制婴儿开发任何新生儿呼吸系统疾病,但随后两个必需的支气管扩张剂治疗。呼吸功能评估胸气体体积的测量(TGV)、气道阻力(生)和功能余气量(FRC)。半胱氨酰LT总产量是量化测量的白三烯E4 (LTE4)尿液样本。尽管所有患者无症状在随访,有明显的证据与CLD婴儿的肺功能异常。CLD婴儿显著升高TGV,原始和FRC值反映了控制相比气道阻塞。尿LTE4水平明显高于CLD婴儿相比,控制(几何平均:741年和337年pmol。mmol-1肌酐分别)。 There was no direct correlation between urinary LTE4 levels in the CLD group and TGV, Raw or FRC values. Although this study is small and a direct correlation between lung function and urinary leukotriene E4 was not demonstrated, pathological lung function and an enhanced urinary leukotriene E4 production in infants with chronic lung disease would tend to suggest that the cysteinyl leukotrienes were involved in the sequelae of this disease.