@article {vagaggini1852，作者= {vagaggini，b和paggiaro，pl和giannini，d和franco，ad and ad and cianchetti，s and cianchetti，s and carnevali，s and taccola，m and taccola，m and bacci，e and e and e and bancalari，and bancalari，l and l＆dente，fl and dente，fl and giuntini，giununtini，giuntini，giuntini，giuntini，giuntini，，c}，title = {短期NO2暴露对诱导痰的效果在正常，哮喘和COPD主题}中，音量= {9}，number = {9}，页面= {1852---1857}，年= {1996}，Publisher = {欧188bet官网地址洲呼吸社会}，摘要= {本研究的目的是评估短期暴露于低水平的二氧化氮（NO2）对气道炎症的影响。我们研究了七个正常，八个轻度哮喘和七个慢性阻塞性肺疾病（COPD）受试者。所有受试者均暴露于空气中，在1小时内暴露于每百万分（ppm）NO2（ppm），在不同的日子和随机顺序中进行中等间歇运动。暴露之前和2小时，评估了症状评分和肺功能测试（PFT）的结果。所有受试者均进行鼻腔灌洗和高渗盐水（HS）吸入两次暴露后2小时收集痰液。哮喘受试者的嗜酸性粒细胞百分比高于正常人，而在空气后HS诱导的痰中的COPD受试者（哮喘患者：中位数13（范围0.4-37）\％\％；正常：0（范围0-2）\％; copd; copd; copd; copd; copd 1.8（范围0.1-19）\％），而COPD患者的中性粒细胞比例比其他两个组高。与空气暴露相比，NO2暴露后的正常，哮喘和COPD受试者在鼻腔灌洗和HS诱导的痰中的PFT值或炎症细胞的百分比没有显着差异，除非一秒钟的强迫呼气量轻度减少COPD患者NO2暴露后2小时FEV1）。 Symptom score showed a mild increase after NO2 exposure both in normal subjects and in COPD patients. We conclude that short-term exposure to 0.3 ppm nitrogen dioxide does not induce an early detectable acute inflammation in proximal airways of normal subjects or of patients with asthma or chronic obstructive pulmonary disease.}, issn = {0903-1936}, URL = {//www.qdcxjkg.com/content/9/9/1852}, eprint = {//www.qdcxjkg.com/content/9/9/1852.full.pdf}, journal = {European Respiratory Journal} }