TY - T1的原发性肺癌患者的预后意义的血小板增多JF -欧洲呼吸杂志》乔和J SP - 1826 LP - 1830欧元六世- 9 - 9 AU - Pedersen LM AU -米尔曼,N Y1 - 1996/09/01 UR - //www.qdcxjkg.com/content/9/9/1826.abstract N2 -在恶性肿瘤患者血小板增多曾被相关疾病阶段,组织学类型和生存。在目前的研究中,血小板增多的流行程度和预后信息提供的血小板计数分析群体的原发性肺癌患者。在诊断时,预处理血小板计数1115个连续的患者进行回顾性记录在在组织学证实的原发性肺癌。综述了所有病人关于组织学类型、肿瘤、节点,转移(TNM)分类阶段和生存。在肺癌患者血小板增多的患病率与550年一系列的连续与良性肺疾病门诊患者。269年手术切除的患者,术后血小板计数记录1 - 3个月后肿瘤的切除。在随访期间,血栓栓塞事件诊断临床或尸检记录。The overall prevalence of thrombocytosis (> 400 x 10(9) platelets.L-1) in the patients with lung cancer was 32%. The frequency of thrombocytosis was significantly higher compared with the control subjects (32 vs 6%; p < 0.0001). Platelet counts differed significantly among subgroups defined by the TNM classification, with the proportion of patients with > 400 x 10(9) platelets.L-1 greatest in the more advanced TNM stages (stage I and II 23% vs stage III and IV 37%; p < 0.0001). Patients with thrombocytosis had a significantly poorer survival than patients with normal platelet counts (p < 0.0001). In a multivariate survival analysis (Cox model), thrombocytosis continued to correlate strongly with poor survival even when adjusted for histological type, sex, age, and TNM stage (p < 0.001). In surgically resected patients, the frequency of preoperative and postoperative thrombocytosis differed significantly (23.0 vs 8.9%; p < 0.0001). Survival rate was significantly reduced in patients with preoperative thrombocytosis (p = 0.005). Thrombocytosis was not associated with an increased incidence of thromboembolism. In conclusion, thrombocytosis is an independent prognostic factor of survival in patients with primary lung cancer. We suggest that platelet counts should be included in future multivariate analyses of survival in patients with lung cancer. ER -