TY - JOUR T1 -打鼾者和睡眠呼吸暂停患者体重指数、年龄和上呼吸道测量值的关系JF -欧洲呼吸杂志JO - Eur Respir J SP - 1801 LP - 1809 DO - 10.1183/09031936.96.09091801 VL - 9 IS - 9 AU - Mayer, P AU - Pepin, JL AU - Bettega, G AU - Veale, D AU - Ferretti, G AU - Deschaux, C AU - Levy,P Y1 - 1996/09/01 UR - //www.qdcxjkg.com/content/9/9/1801.abstract N2 -有报道称,在有或没有阻塞性睡眠呼吸暂停(OSA)的打鼾者中,使用上气道成像可发现咽解剖性和颅面异常。然而,患者的年龄和体重对这些异常的影响仍有待确定。因此,这项研究的目的是评估大量患有或不患有阻塞性睡眠呼吸暂停(OSA)的打鼾者的体重指数(BMI)、年龄和上呼吸道形态之间的关系。140例患者被转诊评估可能的睡眠相关呼吸障碍,并进行了完整的多导睡眠描记术、头影测量术和上呼吸道计算机断层扫描。在整个人群中,OSA患者比打鼾者有更多的上呼吸道异常。然而,当按BMI和年龄细分时,只有瘦弱或年轻的OSA患者在上呼吸道解剖结构上与打鼾者有显著差异。在OSA患者和打鼾者中,口咽和下咽的形状随着BMI的变化而发生显著变化,在BMI最高的组中,由于横轴的减小,口咽和下咽的形状更像球形。另一方面,老年患者(>63岁),无论是打鼾者还是呼吸暂停者,在所有咽部水平上的上呼吸道都比最年轻的一组患者(< 52 yrs). For the total group of patients, upper airway variables explained 26% of the variance in apnoea/hypopnoea index (AHI), whereas in lean (BMI < 27 kg.m-2) or youngest (age < 52 yrs) subjects upper airway variables explained, respectively 69 and 55% of the variance in AHI. In conclusion, in lean or young subjects, upper airway abnormalities explain a major part of the variance in apnoea/hypopnoea index and are likely to play an important physiopathogenic role. This study also suggests that the shape of the pharyngeal lumen in awake subjects is more dependent on body mass index than on the presence of obstructive sleep apnoea. Further investigation looking at upper airway imaging for surgical selection in obstructive sleep apnoea should focus on lean and young patients. ER -