TY - T1的相关性石棉的身体在痰JF -欧洲呼吸杂志》乔和J SP - 680 LP - 686欧元六世- 9 - 4盟Teschler H AU -汤普森,AB非盟- Dollenkamp R盟——都N盟——CostabelU Y1 - 1996/04/01 UR - //www.qdcxjkg.com/content/9/4/680.abstract N2 -职业石棉接触者的痰标本中存在石棉体(ABs)已得到充分的记录。本研究的目的是确定它们与支气管肺泡灌洗(BAL)和肺组织中AB浓度的临床相关性。受试者包括有明确记录的石棉暴露史(n = 93)或BAL液体分析阳性的ABs (n = 42)。有详细记录的AB暴露史的受试者被分为三组:重度(组1,n = 29);中度(2组，n = 31);或偶尔暴露(组3,n = 33)。所有受试者均获得BAL液，21例受试者获得肺组织。为了评估变异性，10名痰液阳性受试者在第2、7、14、30和90天收集后续痰液。标本消化液经膜过滤后，用光学显微镜测定ABs。 The mean sputum AB content was highest in Group 1 (2.4 +/- 5.5 AB.mL-1), lower in Group 2 (0.2 +/- 0.3 AB.mL-1) and lowest in Group 3 (0.1 +/- 0.1 AB.mL-1) suggesting a correlation with cumulative exposure. However, many negative sputum samples were noted, when BAL specimens were positive. The AB content of sputum and BAL specimens did not correlate. ABs were found in sputum of all subjects with a tissue content of > 1,000 AB-cm-3, but in none with contents of < 1,000 AB-cm-3. Substantial variability of ABs was found in the five sequentially collected sputa of 10 initially positive patients (coefficient of variation 28-93%), but only two false negatives were found in these 50 samples. Thus, sputum analysis for asbestos bodies is an insensitive method for assessing the lung asbestos burden, much less sensitive than bronchoalveolar lavage fluid analysis. However, a sputum sample positive for asbestos bodies is suggestive of a high lung asbestos burden. ER -