TY - JOUR T1 -在线自动数据处理对哮喘患儿潮汐呼吸模式分析的改进JF -欧洲呼吸杂志JO - Eur Respir J SP - 1306 LP - 1313 DO - 10.1183/09031936.96.09061306 VL - 9 IS - 6 AU - van der Ent, CK AU - Brackel, HJ AU - Mulder, P AU - Bogaard，JM Y1 - 1996/06/01 UR - //www.qdcxjkg.com/content/9/6/1306.abstract N2 -在潮汐呼吸(TB)期间，达到潮气呼气流量峰值所需的时间占总呼气时间的比例(t PTEF/t E)被用作哮喘儿童气道阻塞的参数。曲线选择偏差是该方法最重要的局限性之一。这项研究评估了三种曲线选择方法，包括一个在线选择和分析结核病曲线的计算机程序(Masterscreen pediatric;Jaeger,德国)。对26名患有哮喘的儿童(4-7岁)进行了结核病分析，分别在甲胆碱刺激前后和随后的支气管扩张后进行。比较了计算机选择曲线、未选择曲线和无偏眼选择曲线得到的TB参数的水平和稳定性。计算机选择曲线的PTEF/t E比值与无偏眼选择曲线的PTEF/t E比值一致(一致限-4.8和+5.8%)，但与未选择曲线的PTEF/t E比值有显著差异。计算机得出的t PTEF/t E比值具有最高水平的稳定性:计算机选择的基线测量的信度系数为0.96，眼睛选择的信度系数为0.84，不选择的信度系数为0.87(在最大稳定性时信度指数= 1)。潮气量、呼吸频率、吸气和呼气时间也通过计算机程序进行准确评估。 The mean t PTEF/t E ratio (computer selection) dropped after methacholine provocation (from 30 +/- 9 to 22 +/- 9% at provocative dose at which forced expiratory volume in one second had dropped > or = 20% from baseline (FEV1-PD20 level), p < 0.001) and was restored after bronchodilation (30 +/- 6%; p < 0.001). We conclude that on-line computer analysis is preferable to no selection and to by-eye selection. The use of the program avoids curve selection bias and enhances the applicability of tidal breathing analysis as a measure of airflow obstruction in young children. ER -