ty -jour t1-非侵入性通气支持不会促进慢性阻塞性肺部疾病急性呼吸衰竭的恢复 - 欧洲呼吸杂志JO -EUR呼吸J SP -1240 LP -1245 LP -1245 VL -9 IS -6 AU -6 AU -BARBE，FAU -BAU- F AU- f au -f au-togores，b au -rubi，m au -pons，s au -maimo，a au -agusti，ag y1-1996/06/01 ur -http：//www.qdcxjkg.com/content.com/content/9/6/6/6/1240。摘要N2-这项调查以前瞻性，随机和控制的方式评估，具有双层阳性气道压力（BIPAP）的无创性通气支持（NIV）是否促进了慢性阻塞性肺部疾病（COPD）患者的急性呼吸衰竭（ARF）的恢复。二十四名患者（平均年龄（+/- SEM）68 +/- 2年），带有COPD（一秒钟的强迫呼气量为33 +/- 2％），他们由于ARF而参加了急诊室（pH 7.33 +/- 0.01;动脉氧张力（PA，O2）6.0 +/- 0.2 kPa;动脉二氧化碳张力（PA，CO2）7.9 +/- 0.3 kPa）最初是随机的。分配给接受NIV的14名患者中有4名（29％）不容忍受。在其余20名患者中，有10名在住院的前3天（每天的3 h持续时间为3 h）在常规医院病房接受了BIPAP。所有20名受试者均用氧，支气管扩张剂和类固醇治疗。在撤回氧疗法和/或BIPAP通气支持后的第一个和第三天，在30分钟之前和30分钟后，我们测量了峰值呼气流，动脉血气值，通气模式，闭塞压力（P0.1）和最大灵感（MIP））和最大呼气（MEP）压力。所有患者都在不需要气管插管和机械通气的情况下出院。 Hospitalization time was similar in both groups (11.3 +/- 1.3 vs 10.6 +/- 0.9 days, control vs BiPAP, respectively). Arterial oxygenation, respiratory acidosis and airflow obstruction improved significantly throughout hospitalization in both groups. By contrast, the ventilatory pattern, P0.1, MIP and MEP did not change. NIVS with BiPAP did not cause any significant difference between groups. We conclude that noninvasive ventilatory support with bilevel positive airway pressure does not facilitate recovery from acute respiratory failure in patients with chronic obstructive pulmonary disease. Furthermore, a substantial proportion of patients (29%) do not tolerate noninvasive ventilatory support under these circumstances. From these results, we cannot recommend the use of noninvasive ventilatory support with bilevel positive airway pressure in the routine management of chronic obstructive pulmonary disease patients recovering from acute respiratory failure. ER -