TY - JOUR T1 -纤溶和炎症过程在胸腔积液JF -欧洲呼吸杂志JO - Eur Respir J SP - 1352 LP - 1356 DO - 10.1183/09031936.95.08081352 VL - 8 IS - 8 AU - philippe - joet, F AU - Alessi, MC AU - Philip-Joet, C AU - Aillaud, M AU - Barriere, AU - Arnaud, A AU - juhanvague，I Y1 - 1995/08/01 UR - //www.qdcxjkg.com/content/8/8/1352.abstract N2 -本研究旨在评价与不同类型胸腔积液相关炎症参数相关的主要纤溶参数。本文对60例胸腔积液患者进行了研究。病因为脓胸10例，肺结核9例，癌症31例，心力衰竭7例，不明病因3例。在血浆样本和胸腔积液标本中定量检测纤溶酶原、纤溶酶原激活物抑制剂1 (PAI-1)和2 (PAI-2)、组织型纤溶酶原激活物(t-PA)、尿激酶(u-PA)和d -二聚体(D-D)。然后将这些数据与炎症或感染性参数相关，即纤维蛋白原、血管性血友病因子(vWF)、红细胞沉降率(ESR)、蛋白质浓度和白细胞计数。胸膜液中D-D水平高于血浆。D-D水平与纤溶酶原激活物或纤溶酶原激活物抑制剂水平均不相关，提示存在其他纤溶途径。肺结核和脓胸患者的PAI水平(PAI活性、PAI-1抗原性、PAI-2抗原性)和vWF水平明显高于癌症或心力衰竭患者。炎症和纤溶参数之间的回归分析显示，胸膜PAI水平与胸膜中性粒细胞计数、vWF水平和血浆纤维蛋白原水平显著相关。 D-D levels were correlated with blood ESR. No significant difference in pleural t-PA, u-PA and D-D levels was observed between aetiologies. The highest pleural t-PA and u-PA values were noted in patients with cancer, especially lymphoma. Plasma t-PA levels were higher inpatients with pleural effusion secondary to congestive heart failure, but this difference did not reach statistical significance.(ABSTRACT TRUNCATED AT 250 WORDS) ER -