@article {lundahl1188，作者= {lundahl，J和Hallden，G and Skold，CM}，title = {人类血单核细胞，但不是肺泡巨噬细胞，揭示了CD11B/CD1B/CD18的表达和粘附在受体依赖性激活上的表达和粘附性的增加= {9}，number = {6}，pages = {1188--1194}，年= {1996}，publisher = {欧洲呼吸社会}，188bet官网地址摘要= {beta 2整合蛋白受体CD11b/cd18介导了内皮层的粘附力衬里以及细胞外基质组件。对本研究进行了研究，以研究与激活状态相关的CD11b/CD18定量水平和粘附特性。BMS和AM是从健康受试者中招募的。通过流式细胞术技术和粘附涂层表面的粘附特性对CD11b/CD18的表面表达进行定量分析。在其他实验中使用了受体独立刺激（phorbol-12-麦芽孢子-13-乙酸盐（PMA）和离子霉素）。通过流式细胞术和免疫荧光显微镜评估细胞内存储的CD11b/CD18。FMLP激活后，CD11b/CD18在静息BMS上的表面表达增加了五倍（P \ <0.01）。在静止AMS上，与静止的BMS相比，CD11b/CD18的表面表达明显更高（P \ <0.01），但使用FMLP，PMA或离子霉素激活后并没有进一步增加。 In contrast to BMs, no evidence for an additional intracellular pool of CD11b/CD18 was found in AMs. The adherence of resting BMs did not significantly differ from the adherence of resting AMs. After fMLP activation, the adherence of BMs, but not AMs, increased significantly (p \< 0.05). Our results indicate that in vivo differentiation of human blood monocytes into alveolar macrophages implies reduced responsiveness to fMLP in terms of CD11b/CD18 upregulation and adhesion properties, and that the lack of upregulation of CD11b/CD18 on alveolar macrophages presumably depends on the absence of an additional intracellular pool.}, issn = {0903-1936}, URL = {//www.qdcxjkg.com/content/9/6/1188}, eprint = {//www.qdcxjkg.com/content/9/6/1188.full.pdf}, journal = {European Respiratory Journal} }