TY - T1的呼吸变化驱动占呼吸困难的大小在哮喘患者支气管狭窄JF -欧洲呼吸杂志》乔和J SP - 1155 LP - 1159欧元六世- 9 - 6盟Bellofiore年代盟——Ricciardolo FL盟——Ciancio N盟——Sapienza马盟——Patane盟——Mistretta AU -玛丽亚,顾Y1 - 1996/06/01 UR - //www.qdcxjkg.com/content/9/6/1155.abstract N2 -评估个人间的差异是否呼吸困难被哮喘受试者的相同级别的气道狭窄可能取决于不同的呼吸变化驱动,我们评估气道口径的变化之间的关系,在由甲胆碱引起的进行性支气管收缩过程中神经肌肉输出量和呼吸困难率的变化。我们研究了18名无症状哮喘受试者(年龄18-36岁;男11例，女7例)肺功能正常。在基线和吸入两倍浓度的甲胆碱气溶胶(MCh)后测量呼吸困难(Borg量表)、口腔咬合压力(P0.1)和一秒用力呼气量(FEV1)。MCh引起的进行性支气管收缩与P0.1和呼吸困难的进行性增加有关。呼吸困难评分与FEV1的下降或P0.1的增加呈线性相关。然而，呼吸困难评分和相应的FEV1下降百分比之间的斜率值显示出很大的个体间变异性(0.05-0.32;变异系数(CoV) 43%)。 By contrast, the slope values of the relationship between dyspnoea score and the corresponding percent increase in P0.1 ranged 0.02-0.05 (CoV = 14%), indicating a more homogeneous response to dyspnoea for the same change in P0.1. At the highest MCh concentration, the dyspnoea score was linearly related to the corresponding change in P0.1 (r = 0.91; p < 0.01), but not to the corresponding percentage fall in FEV1 (r = 0.28). These results show that the interindividual differences in dyspnoea perceived by asthmatic subjects for the same level of airway narrowing are associated with different changes in respiratory drive during bronchoconstriction. ER -