TY - T1的烧伤患者的肺单纯疱疹JF -欧洲呼吸杂志》乔和J SP - 2313 LP - 2317欧元六世- 9 - 11盟拜尔斯RJ盟——Hasleton PS AU -奎格利,非盟——丹尼特,C盟——Klapper PE盟——Cleator通用非盟- Faragher EB Y1 - 1996/11/01 UR - //www.qdcxjkg.com/content/9/11/2313.abstract N2 -在这项研究中我们旨在确定单纯疱疹病毒(HSV)的发病率在烧伤患者的肺,及其与成人呼吸窘迫综合征(ARDS)的存在和肺炎。Haematoxylin and eosin (H&E), and immunohistochemical (IHC) staining for HSV was performed on lung tissue from 54 patients who had died following burn injury and from nine control cases. Polymerase chain reaction (PCR) for HSV deoxyribonucleic acid (DNA) was performed on a subset both of burns cases and controls. No viral inclusions were detected in H&E sections, but 50% of the burns cases were positive for HSV by IHC staining; no control cases were positive. Nuclear and cytoplasmic immunopositivity for HSV was seen in macrophages and epithelial lining cells. HSV was strongly associated with ARDS (p=0.007), but not with pneumonia (p=0.577). The relative risk of HSV infection was higher for cases with ARDS (2.21) than for those with pneumonia (1.26). PCR for HSV DNA was positive in three out of five burns cases, and in one out of five control cases. Immunohistochemical staining is more sensitive for the detection of herpes simplex virus than haematoxylin and eosin staining for detection of viral inclusions. Burns cases have a high incidence of pulmonary herpes simplex virus infection. Polymerase chain reaction results may not be fully representative due to problems of tissue necrosis postmortem. Pulmonary herpes simplex virus is strongly associated with adult respiratory distress syndrome and the two may be causally linked. Early detection and treatment of pulmonary herpes simplex virus in burns patients may reduce pulmonary complications and mortality. ER -