TY -的T1 CD44的表达和整合蛋白在支气管粘膜的正常和轻度哮喘受试者JF -欧洲呼吸杂志》乔和J SP - 2236 LP - 2242欧元六世- 9 - 11盟Peroni DG盟——元首,R AU -布拉德,P AU -羽毛,IH盟——Montefort年代AU -霍沃斯,PH值非盟-琼斯,DB AU -霍尔盖特,圣Y1 - 1996/11/01 UR - //www.qdcxjkg.com/content/9/11/2236.abstract N2 -我们有调查细胞表面标记物的表达和白细胞细胞粘附分子在免疫组织化学从10轻度过敏性哮喘患者支气管活检和8正常,nonatopic科目。Significantly increased numbers of eosinophils (p<0.01) were evident in the bronchial submucosa of asthmatic subjects. In epithelium there were more CD44+ (p<0.02) and lymphocyte function-associated antigen-1 (LFA-1)+ (p<0.06) leucocytes in asthmatics than in normal subjects. Bronchial epithelial cells stained positively with anti-CD44 monoclonal antibodies (moAb) in both groups; however, when the staining was expressed as percentage of the total basement membrane, a considerable and highly significant increase was observed in the asthmatics (median 80 vs 22%, p=0.003). Few leucocytes were positive for very late activation antigen (VLA)-1, VLA-2 and VLA-4. The moAb for VLA-6 stained the basement membrane of the bronchial epithelium; while intracellular adhesion molecule-1 (ICAM-1) and vascular cell adhesion molecule-1 (VCAM-1) were constitutively expressed in endothelium. A positive correlation was found between LFA-1+ cells and activated eosinophils (EG2+) in the submucosa (p<0.005; r(s)=0.80). We conclude that even in mild asthma there is evidence of increased expression of cell surface ligands, and suggest that adhesive mechanisms play a role both in cell recruitment and disease activity. ER -