@文章{Peroni2236，作者= {Peroni, DG和Djukanovic, R和Bradding, P和Feather, IH和Montefort, S和Howarth, PH和Jones, DB和Holgate, ST}，标题={正常和轻度哮喘患者支气管黏膜CD44和整合素的表达}，卷={9}，数={11}，页数={2236—2242}，年份= {1996}，doi ={10.1183/09031936.96.09112236}，出版商={欧洲呼吸学会}，188bet官网地址我们用免疫组织化学方法研究了10例轻度特应性哮喘患者和8例正常非特应性哮喘患者支气管活检中细胞表面标记物和白细胞粘附分子的表达。哮喘组支气管黏膜下层嗜酸性粒细胞数量明显增加(p\<0.01)。哮喘患者上皮细胞中CD44+ (p <0.02)和淋巴细胞功能相关抗原-1 (LFA-1)+白细胞(p <0.06)明显高于正常对照组。两组支气管上皮细胞抗cd44单克隆抗体(moAb)染色均呈阳性;然而，当染色以总基底膜的百分比表示时，在哮喘患者中观察到相当大且非常显著的增加(中位数为80 vs 22\%， p=0.003)。极晚激活抗原(VLA)-1、VLA-2和VLA-4阳性的白细胞较少。VLA-6的moAb染色支气管上皮基底膜;细胞内粘附分子-1 (ICAM-1)和血管细胞粘附分子-1 (VCAM-1)在内皮细胞中呈组成型表达。粘膜下层LFA-1+细胞与激活的嗜酸性粒细胞(EG2+)呈正相关(p\<0.005; r(s)=0.80). We conclude that even in mild asthma there is evidence of increased expression of cell surface ligands, and suggest that adhesive mechanisms play a role both in cell recruitment and disease activity.}, issn = {0903-1936}, URL = {//www.qdcxjkg.com/content/9/11/2236}, eprint = {//www.qdcxjkg.com/content/9/11/2236.full.pdf}, journal = {European Respiratory Journal} }